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Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.

Publication ,  Journal Article
Sanford, JA; Nogiec, CD; Lindholm, ME; Adkins, JN; Amar, D; Dasari, S; Drugan, JK; Fernández, FM; Radom-Aizik, S; Schenk, S; Snyder, MP ...
Published in: Cell
June 25, 2020

Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

June 25, 2020

Volume

181

Issue

7

Start / End Page

1464 / 1474

Location

United States

Related Subject Headings

  • Young Adult
  • Research Design
  • Physical Endurance
  • Oxygen Consumption
  • Middle Aged
  • Male
  • Humans
  • Female
  • Exercise
  • Developmental Biology
 

Citation

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Sanford, J. A., Nogiec, C. D., Lindholm, M. E., Adkins, J. N., Amar, D., Dasari, S., … Molecular Transducers of Physical Activity Consortium, . (2020). Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell, 181(7), 1464–1474. https://doi.org/10.1016/j.cell.2020.06.004
Sanford, James A., Christopher D. Nogiec, Malene E. Lindholm, Joshua N. Adkins, David Amar, Surendra Dasari, Jonelle K. Drugan, et al. “Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.Cell 181, no. 7 (June 25, 2020): 1464–74. https://doi.org/10.1016/j.cell.2020.06.004.
Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, et al. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell. 2020 Jun 25;181(7):1464–74.
Sanford, James A., et al. “Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.Cell, vol. 181, no. 7, June 2020, pp. 1464–74. Pubmed, doi:10.1016/j.cell.2020.06.004.
Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, Drugan JK, Fernández FM, Radom-Aizik S, Schenk S, Snyder MP, Tracy RP, Vanderboom P, Trappe S, Walsh MJ, Molecular Transducers of Physical Activity Consortium. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell. 2020 Jun 25;181(7):1464–1474.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

June 25, 2020

Volume

181

Issue

7

Start / End Page

1464 / 1474

Location

United States

Related Subject Headings

  • Young Adult
  • Research Design
  • Physical Endurance
  • Oxygen Consumption
  • Middle Aged
  • Male
  • Humans
  • Female
  • Exercise
  • Developmental Biology