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Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs.

Publication ,  Journal Article
Anwar, A; Anwar, IJ; Delafontaine, P
Published in: Trends in cardiovascular medicine
November 2015

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as demonstrated by recent trials using this type of drug. This review explores the latest available data, including recent, randomized, clinical trials, controversies, and pathophysiology of the adverse effects of COX-inhibition.

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Published In

Trends in cardiovascular medicine

DOI

EISSN

1873-2615

ISSN

1050-1738

Publication Date

November 2015

Volume

25

Issue

8

Start / End Page

726 / 735

Related Subject Headings

  • Sulfones
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Prevalence
  • Naproxen
  • Middle Aged
  • Male
  • Lactones
  • Humans
  • Homeostasis
 

Citation

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ICMJE
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Anwar, A., Anwar, I. J., & Delafontaine, P. (2015). Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs. Trends in Cardiovascular Medicine, 25(8), 726–735. https://doi.org/10.1016/j.tcm.2015.03.006
Anwar, Asif, Imran John Anwar, and Patrice Delafontaine. “Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs.Trends in Cardiovascular Medicine 25, no. 8 (November 2015): 726–35. https://doi.org/10.1016/j.tcm.2015.03.006.
Anwar A, Anwar IJ, Delafontaine P. Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs. Trends in cardiovascular medicine. 2015 Nov;25(8):726–35.
Anwar, Asif, et al. “Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs.Trends in Cardiovascular Medicine, vol. 25, no. 8, Nov. 2015, pp. 726–35. Epmc, doi:10.1016/j.tcm.2015.03.006.
Anwar A, Anwar IJ, Delafontaine P. Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs. Trends in cardiovascular medicine. 2015 Nov;25(8):726–735.
Journal cover image

Published In

Trends in cardiovascular medicine

DOI

EISSN

1873-2615

ISSN

1050-1738

Publication Date

November 2015

Volume

25

Issue

8

Start / End Page

726 / 735

Related Subject Headings

  • Sulfones
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Prevalence
  • Naproxen
  • Middle Aged
  • Male
  • Lactones
  • Humans
  • Homeostasis