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The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease.

Publication ,  Journal Article
Davel, AP; Anwar, IJ; Jaffe, IZ
Published in: Current opinion in nephrology and hypertension
March 2017

Endothelial dysfunction is an early feature of vascular disease induced by cardiovascular risk factors (CRFs). In growing populations with obesity, diabetes, hypertension, and heart failure, mineralocorticoid receptor antagonism improves endothelial function. This review summarizes recent advances in our understanding of the specific role of endothelial cell mineralocorticoid receptor in vascular function in health and disease.Using transgenic mice with mineralocorticoid receptor expression specifically modulated in endothelial cells, recent studies support the emerging concept that while endothelial cell mineralocorticoid receptor may be protective in health, in the presence of CRFs, endothelial cell mineralocorticoid receptor activity contributes to endothelial dysfunction and progression of vascular disease. Proposed mechanisms include a role for endothelial cell mineralocorticoid receptor in decreased nitric oxide production and bioavailability, increased vascular oxidative stress, regulation of epithelial sodium channels that enhance vascular stiffness, and increased endothelial cell adhesion molecules promoting inflammation. The role of endothelial cell mineralocorticoid receptor may also depend on the sex, race, or vascular bed involved.Recent advances support the idea that endothelial cell mineralocorticoid receptor is a mediator of the switch from vascular health to disease in response to CRFs. Further investigation of the molecular mechanism is underway to identify therapeutic interventions that will limit the detrimental effects of endothelial cell mineralocorticoid receptor in patients at cardiovascular risk.

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Published In

Current opinion in nephrology and hypertension

DOI

EISSN

1473-6543

ISSN

1062-4821

Publication Date

March 2017

Volume

26

Issue

2

Start / End Page

97 / 104

Related Subject Headings

  • Vascular Stiffness
  • Urology & Nephrology
  • Signal Transduction
  • Risk Factors
  • Receptors, Mineralocorticoid
  • Oxidative Stress
  • Nitric Oxide
  • Inflammation
  • Humans
  • Endothelium, Vascular
 

Citation

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Davel, A. P., Anwar, I. J., & Jaffe, I. Z. (2017). The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease. Current Opinion in Nephrology and Hypertension, 26(2), 97–104. https://doi.org/10.1097/mnh.0000000000000306
Davel, Ana P., Imran J. Anwar, and Iris Z. Jaffe. “The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease.Current Opinion in Nephrology and Hypertension 26, no. 2 (March 2017): 97–104. https://doi.org/10.1097/mnh.0000000000000306.
Davel AP, Anwar IJ, Jaffe IZ. The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease. Current opinion in nephrology and hypertension. 2017 Mar;26(2):97–104.
Davel, Ana P., et al. “The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease.Current Opinion in Nephrology and Hypertension, vol. 26, no. 2, Mar. 2017, pp. 97–104. Epmc, doi:10.1097/mnh.0000000000000306.
Davel AP, Anwar IJ, Jaffe IZ. The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease. Current opinion in nephrology and hypertension. 2017 Mar;26(2):97–104.

Published In

Current opinion in nephrology and hypertension

DOI

EISSN

1473-6543

ISSN

1062-4821

Publication Date

March 2017

Volume

26

Issue

2

Start / End Page

97 / 104

Related Subject Headings

  • Vascular Stiffness
  • Urology & Nephrology
  • Signal Transduction
  • Risk Factors
  • Receptors, Mineralocorticoid
  • Oxidative Stress
  • Nitric Oxide
  • Inflammation
  • Humans
  • Endothelium, Vascular