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Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer.

Publication ,  Journal Article
Rhodin, KE; Raman, V; Jawitz, OK; Voigt, SL; Farrow, NE; Harpole, DH; Tong, BC; D'Amico, TA
Published in: Ann Thorac Surg
February 2021

BACKGROUND: Induction therapy for patients with cT2N0M0 esophageal cancer is controversial. We performed a retrospective cohort analysis of the National Cancer Database to examine the patterns of use of induction therapy for this population. METHODS: The National Cancer Database was queried for patients with cT2N0M0 esophageal cancer who underwent esophagectomy (2004-2015). Patients were stratified by upfront surgery or induction therapy. Overall survival was analyzed and a multivariable logistic regression performed to identify factors associated with receipt of induction therapy. RESULTS: Overall 2540 patients met study criteria: 1177 (46%) received upfront esophagectomy and 1363 (53%) received induction therapy. Patients receiving induction therapy were more likely to be younger, male, without comorbidities, privately insured, and treated at a nonacademic center. These patients were also less likely to be treated in highest volume surgery centers. In multivariable regression, factors independently associated with receipt of induction therapy included later year of diagnosis, increasing tumor size, and increasing tumor grade. Factors associated with upfront esophagectomy included advancing age, comorbidities, lack of insurance, geographic location, and highest volume centers. The receipt of induction chemotherapy was not associated with a survival benefit compared with no induction therapy. CONCLUSIONS: Several patient-, treatment center-, and tumor-related factors are associated with receipt of induction therapy for cT2N0M0 esophageal cancer, although induction therapy is not associated with a survival benefit. Further inquiry into these differences and the potential benefit or lack thereof of induction therapy should be conducted to provide more equitable and appropriate care for patients with esophageal cancer.

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Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

February 2021

Volume

111

Issue

2

Start / End Page

440 / 447

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Respiratory System
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Induction Chemotherapy
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

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MLA
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Rhodin, K. E., Raman, V., Jawitz, O. K., Voigt, S. L., Farrow, N. E., Harpole, D. H., … D’Amico, T. A. (2021). Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer. Ann Thorac Surg, 111(2), 440–447. https://doi.org/10.1016/j.athoracsur.2020.05.089
Rhodin, Kristen E., Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Norma E. Farrow, David H. Harpole, Betty C. Tong, and Thomas A. D’Amico. “Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer.Ann Thorac Surg 111, no. 2 (February 2021): 440–47. https://doi.org/10.1016/j.athoracsur.2020.05.089.
Rhodin KE, Raman V, Jawitz OK, Voigt SL, Farrow NE, Harpole DH, et al. Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer. Ann Thorac Surg. 2021 Feb;111(2):440–7.
Rhodin, Kristen E., et al. “Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer.Ann Thorac Surg, vol. 111, no. 2, Feb. 2021, pp. 440–47. Pubmed, doi:10.1016/j.athoracsur.2020.05.089.
Rhodin KE, Raman V, Jawitz OK, Voigt SL, Farrow NE, Harpole DH, Tong BC, D’Amico TA. Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer. Ann Thorac Surg. 2021 Feb;111(2):440–447.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

February 2021

Volume

111

Issue

2

Start / End Page

440 / 447

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Respiratory System
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Induction Chemotherapy
  • Humans
  • Follow-Up Studies
  • Female