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Rising occurrence of hypocitraturia and hyperoxaluria associated with increasing prevalence of stone disease in calcium kidney stone formers.

Publication ,  Journal Article
Youssef, RF; Martin, JW; Sakhaee, K; Poindexter, J; Dianatnejad, S; Scales, CD; Preminger, GM; Lipkin, ME
Published in: Scand J Urol
October 2020

OBJECTIVE: To evaluate metabolic risk factors in calcium kidney stone formers from two different decades, comparing changes in metabolic profiles over time. METHODS: A retrospective analysis was performed of calcium kidney stone formers who underwent metabolic evaluation of urolithiasis with 24-hour urine collections at a single institution. There were 309 patients evaluated from 1988 to 1994 (Group A), and 229 patients from 2007 to 2010 (Group B). A comparison between both groups was performed to assess changes in demographics and in metabolic stone profiles. RESULTS: Comparing Group A to Group B, the percentage of females increased from 43 to 56%, obese patients (BMI ≥ 30) increased from 22 to 35%, and patients ≥ 50 years increased from 29 to 47% (all p < 0.005). A greater percentage of patients had hypocitraturia in the recent cohort (46-60%, p = 0.001), with hypocitraturia significantly more frequent in obese patients (p = 0.005). Hyperoxaluria was also increased in Group B compared to Group A (23-30% p = 0.07), a finding that was significant in males (32-53%, p = 0.001). CONCLUSIONS: Urolithiasis has increased in females, obese, and older patients, consistent with population-based studies. We report a rising incidence of hypocitraturia and hyperoxaluria in the contemporary cohort, particularly in obese patients and in males, respectively. Further studies are needed to better characterize the metabolic changes corresponding to the increase in stone disease.

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Published In

Scand J Urol

DOI

EISSN

2168-1813

Publication Date

October 2020

Volume

54

Issue

5

Start / End Page

426 / 430

Location

Sweden

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Recurrence
  • Prevalence
  • Middle Aged
  • Male
  • Kidney Calculi
  • Hyperoxaluria
  • Humans
  • Female
 

Citation

APA
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MLA
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Youssef, R. F., Martin, J. W., Sakhaee, K., Poindexter, J., Dianatnejad, S., Scales, C. D., … Lipkin, M. E. (2020). Rising occurrence of hypocitraturia and hyperoxaluria associated with increasing prevalence of stone disease in calcium kidney stone formers. Scand J Urol, 54(5), 426–430. https://doi.org/10.1080/21681805.2020.1794955
Youssef, Ramy F., Jeremy W. Martin, Khashayar Sakhaee, John Poindexter, Sharmin Dianatnejad, Charles D. Scales, Glenn M. Preminger, and Michael E. Lipkin. “Rising occurrence of hypocitraturia and hyperoxaluria associated with increasing prevalence of stone disease in calcium kidney stone formers.Scand J Urol 54, no. 5 (October 2020): 426–30. https://doi.org/10.1080/21681805.2020.1794955.
Youssef RF, Martin JW, Sakhaee K, Poindexter J, Dianatnejad S, Scales CD, et al. Rising occurrence of hypocitraturia and hyperoxaluria associated with increasing prevalence of stone disease in calcium kidney stone formers. Scand J Urol. 2020 Oct;54(5):426–30.
Youssef, Ramy F., et al. “Rising occurrence of hypocitraturia and hyperoxaluria associated with increasing prevalence of stone disease in calcium kidney stone formers.Scand J Urol, vol. 54, no. 5, Oct. 2020, pp. 426–30. Pubmed, doi:10.1080/21681805.2020.1794955.
Youssef RF, Martin JW, Sakhaee K, Poindexter J, Dianatnejad S, Scales CD, Preminger GM, Lipkin ME. Rising occurrence of hypocitraturia and hyperoxaluria associated with increasing prevalence of stone disease in calcium kidney stone formers. Scand J Urol. 2020 Oct;54(5):426–430.

Published In

Scand J Urol

DOI

EISSN

2168-1813

Publication Date

October 2020

Volume

54

Issue

5

Start / End Page

426 / 430

Location

Sweden

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Recurrence
  • Prevalence
  • Middle Aged
  • Male
  • Kidney Calculi
  • Hyperoxaluria
  • Humans
  • Female