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Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh.

Publication ,  Journal Article
Leung, DT; Rahman, MA; Mohasin, M; Riyadh, MA; Patel, SM; Alam, MM; Chowdhury, F; Khan, AI; Kalivoda, EJ; Aktar, A; Bhuiyan, MS; LaRocque, RC ...
Published in: Clin Vaccine Immunol
August 2011

Children bear a large component of the global burden of cholera. Despite this, little is known about immune responses to cholera in children, especially those under 5 years of age. Cholera vaccine studies have demonstrated lower long-term protective efficacy in young children than in older children and adults. Memory B cell (MBC) responses may correlate with duration of protection following infection and vaccination. Here we report a comparison of immune responses in young children (3 to 5 years of age; n = 17), older children (6 to 17 years of age; n = 17), and adults (18 to 60 years of age; n = 68) hospitalized with cholera in Dhaka, Bangladesh. We found that young children had lower baseline vibriocidal antibody titers and higher fold increases in titer between day 2 and day 7 than adults. Young children had higher baseline IgG plasma antibody levels to Vibrio cholerae antigens, although the magnitudes of responses at days 7 and 30 were similar across age groups. As a surrogate marker for mucosal immune responses, we assessed day 7 antibody-secreting cell (ASC) responses. These were comparable across age groups, although there was a trend for older age groups to have higher levels of lipopolysaccharide-specific IgA ASC responses. All age groups developed comparable MBC responses to V. cholerae lipopolysaccharide and cholera toxin B subunit at day 30. These findings suggest that young children are able to mount robust vibriocidal, plasma antibody, ASC, and MBC responses against V. cholerae O1, suggesting that under an optimal vaccination strategy, young children could achieve protective efficacy comparable to that induced in adults.

Duke Scholars

Published In

Clin Vaccine Immunol

DOI

EISSN

1556-679X

Publication Date

August 2011

Volume

18

Issue

8

Start / End Page

1317 / 1325

Location

United States

Related Subject Headings

  • Young Adult
  • Vibrio cholerae O1
  • Time Factors
  • Middle Aged
  • Microbiology
  • Male
  • Immunology
  • Immunologic Memory
  • Immunoglobulin G
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Leung, D. T., Rahman, M. A., Mohasin, M., Riyadh, M. A., Patel, S. M., Alam, M. M., … Ryan, E. T. (2011). Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Clin Vaccine Immunol, 18(8), 1317–1325. https://doi.org/10.1128/CVI.05124-11
Leung, Daniel T., Mohammad Arif Rahman, M. Mohasin, M Asrafuzzaman Riyadh, Sweta M. Patel, Mohammad Murshid Alam, Fahima Chowdhury, et al. “Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh.Clin Vaccine Immunol 18, no. 8 (August 2011): 1317–25. https://doi.org/10.1128/CVI.05124-11.
Leung DT, Rahman MA, Mohasin M, Riyadh MA, Patel SM, Alam MM, Chowdhury F, Khan AI, Kalivoda EJ, Aktar A, Bhuiyan MS, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Clin Vaccine Immunol. 2011 Aug;18(8):1317–1325.

Published In

Clin Vaccine Immunol

DOI

EISSN

1556-679X

Publication Date

August 2011

Volume

18

Issue

8

Start / End Page

1317 / 1325

Location

United States

Related Subject Headings

  • Young Adult
  • Vibrio cholerae O1
  • Time Factors
  • Middle Aged
  • Microbiology
  • Male
  • Immunology
  • Immunologic Memory
  • Immunoglobulin G
  • Humans