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Metastatic Pancreatic Cancer: ASCO Guideline Update.

Publication ,  Journal Article
Sohal, DPS; Kennedy, EB; Cinar, P; Conroy, T; Copur, MS; Crane, CH; Garrido-Laguna, I; Lau, MW; Johnson, T; Krishnamurthi, S; Moravek, C ...
Published in: J Clin Oncol
September 20, 2020

PURPOSE: The aim of this work was to provide an update to the ASCO guideline on metastatic pancreatic cancer pertaining to recommendations for therapy options after first-line treatment. METHODS: ASCO convened an Expert Panel and conducted a systematic review to update guideline recommendations for second-line therapy for metastatic pancreatic cancer. RESULTS: One randomized controlled trial of olaparib versus placebo, one report on phase I and II studies of larotrectinib, and one report on phase I and II studies of entrectinib met the inclusion criteria and inform the guideline update. RECOMMENDATIONS: New or updated recommendations for germline and somatic testing for microsatellite instability high/mismatch repair deficiency, BRCA mutations, and TRK alterations are provided for all treatment-eligible patients to select patients for recommended therapies, including pembrolizumab, olaparib, larotrectinib, or entrectinib, or potential clinical trials. The Expert Panel continues to endorse the remaining recommendations for second-line chemotherapy, as well as other recommendations related to treatment, follow-up, and palliative care from the 2018 version of this guideline. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

September 20, 2020

Volume

38

Issue

27

Start / End Page

3217 / 3230

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Sohal, D. P. S., Kennedy, E. B., Cinar, P., Conroy, T., Copur, M. S., Crane, C. H., … Laheru, D. (2020). Metastatic Pancreatic Cancer: ASCO Guideline Update. J Clin Oncol, 38(27), 3217–3230. https://doi.org/10.1200/JCO.20.01364
Sohal, Davendra P. S., Erin B. Kennedy, Pelin Cinar, Thierry Conroy, Mehmet S. Copur, Christopher H. Crane, Ignacio Garrido-Laguna, et al. “Metastatic Pancreatic Cancer: ASCO Guideline Update.J Clin Oncol 38, no. 27 (September 20, 2020): 3217–30. https://doi.org/10.1200/JCO.20.01364.
Sohal DPS, Kennedy EB, Cinar P, Conroy T, Copur MS, Crane CH, et al. Metastatic Pancreatic Cancer: ASCO Guideline Update. J Clin Oncol. 2020 Sep 20;38(27):3217–30.
Sohal, Davendra P. S., et al. “Metastatic Pancreatic Cancer: ASCO Guideline Update.J Clin Oncol, vol. 38, no. 27, Sept. 2020, pp. 3217–30. Pubmed, doi:10.1200/JCO.20.01364.
Sohal DPS, Kennedy EB, Cinar P, Conroy T, Copur MS, Crane CH, Garrido-Laguna I, Lau MW, Johnson T, Krishnamurthi S, Moravek C, O’Reilly EM, Philip PA, Pant S, Shah MA, Sahai V, Uronis HE, Zaidi N, Laheru D. Metastatic Pancreatic Cancer: ASCO Guideline Update. J Clin Oncol. 2020 Sep 20;38(27):3217–3230.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

September 20, 2020

Volume

38

Issue

27

Start / End Page

3217 / 3230

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences