Successful Combination of Neuraxial and Regional Anesthesia in a Child With Advanced Spinal Muscular Atrophy Type 1 Receiving Maintenance Nusinersen Therapy: A Case Report.
Publication
, Journal Article
Brown, AF; Einhorn, LM
Published in: A A Pract
April 2020
Spinal muscular atrophy (SMA) is an autosomal recessive condition characterized by degeneration of the anterior horn cells of the spinal cord, which causes progressive muscle atrophy and weakness. SMA type 1 is the most common type and is associated with severe disability and early mortality. Concomitant restrictive respiratory physiology often manifests with significant implications for anesthetic management. Here, we describe a successful spinal anesthetic for orthopedic surgery in an SMA type 1 patient receiving intrathecal nusinersen maintenance therapy, an antisense oligonucleotide designed to increase expression of the survival motor neuron protein, and the first US Food and Drug Administration-approved drug to treat SMA.
Duke Scholars
Published In
A A Pract
DOI
EISSN
2575-3126
Publication Date
April 2020
Volume
14
Issue
6
Start / End Page
e01206
Location
United States
Related Subject Headings
- Oligonucleotides
- Muscular Atrophy, Spinal
- Injections, Spinal
- Humans
- Child
- Anesthesia, Conduction
Citation
APA
Chicago
ICMJE
MLA
NLM
Brown, A. F., & Einhorn, L. M. (2020). Successful Combination of Neuraxial and Regional Anesthesia in a Child With Advanced Spinal Muscular Atrophy Type 1 Receiving Maintenance Nusinersen Therapy: A Case Report. A A Pract, 14(6), e01206. https://doi.org/10.1213/XAA.0000000000001206
Brown, Alison F., and Lisa M. Einhorn. “Successful Combination of Neuraxial and Regional Anesthesia in a Child With Advanced Spinal Muscular Atrophy Type 1 Receiving Maintenance Nusinersen Therapy: A Case Report.” A A Pract 14, no. 6 (April 2020): e01206. https://doi.org/10.1213/XAA.0000000000001206.
Brown AF, Einhorn LM. Successful Combination of Neuraxial and Regional Anesthesia in a Child With Advanced Spinal Muscular Atrophy Type 1 Receiving Maintenance Nusinersen Therapy: A Case Report. A A Pract. 2020 Apr;14(6):e01206.
Brown, Alison F., and Lisa M. Einhorn. “Successful Combination of Neuraxial and Regional Anesthesia in a Child With Advanced Spinal Muscular Atrophy Type 1 Receiving Maintenance Nusinersen Therapy: A Case Report.” A A Pract, vol. 14, no. 6, Apr. 2020, p. e01206. Pubmed, doi:10.1213/XAA.0000000000001206.
Brown AF, Einhorn LM. Successful Combination of Neuraxial and Regional Anesthesia in a Child With Advanced Spinal Muscular Atrophy Type 1 Receiving Maintenance Nusinersen Therapy: A Case Report. A A Pract. 2020 Apr;14(6):e01206.
Published In
A A Pract
DOI
EISSN
2575-3126
Publication Date
April 2020
Volume
14
Issue
6
Start / End Page
e01206
Location
United States
Related Subject Headings
- Oligonucleotides
- Muscular Atrophy, Spinal
- Injections, Spinal
- Humans
- Child
- Anesthesia, Conduction