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Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels.

Publication ,  Journal Article
Patel, SP; Khanna, R; Choi, J; Williams, KA; Roh, YS; Hong, MS; Sutaria, NH; Pritchard, T; Kwatra, MM; Kwatra, SG
Published in: J Am Acad Dermatol
February 2021

BACKGROUND: Pruritus is a common symptom that can significantly reduce quality of life through sleep disruption. OBJECTIVE: To examine features of disturbed sleep in patients with chronic pruritic dermatoses and test the hypothesis that systemic inflammation may serve as a biomarker for impaired sleep in these patients. METHODS: Cross-sectional analysis of the National Health and Nutrition Examination Survey investigating systemic inflammation using C-reactive protein (CRP) levels. Logistic regression was used to compare patients with and without sleep disturbances, adjusting for demographics (model 1) and medical comorbidities (model 2). RESULTS: Chronic pruritic dermatoses were associated with multiple sleep disturbances, including nighttime awakenings (model 1: odds ratio [OR], 1.646; 95% confidence interval [CI], 1.031-2.627; model 2: OR, 1.329; 95% CI, 0.888-1.989) and early morning awakening (model 1: OR, 1.669, 95% CI, 1.118-2.493; model 2: OR, 1.582; 95% CI, 1.008-2.481). Mean CRP levels were 52.8% higher among patients with pruritic dermatoses reporting trouble sleeping compared with those who did not (0.663 vs 0.434 mg/dL; P = .034). Trouble sleeping was also positively correlated with CRP levels (β = 0.142, P = .025). LIMITATIONS: Potential recall bias among participants. CONCLUSIONS: In addition to confirming sleep disturbances with pruritic dermatoses, we found these disturbances are more likely to present with elevated CRP levels. Clinicians should consider the potential risk for sleep-related and cardiac comorbidities in patients diagnosed with itchy skin conditions.

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Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

February 2021

Volume

84

Issue

2

Start / End Page

265 / 272

Location

United States

Related Subject Headings

  • Sleep Wake Disorders
  • Risk Assessment
  • Quality of Life
  • Pruritus
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dermatology & Venereal Diseases
  • Cross-Sectional Studies
 

Citation

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Patel, S. P., Khanna, R., Choi, J., Williams, K. A., Roh, Y. S., Hong, M. S., … Kwatra, S. G. (2021). Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels. J Am Acad Dermatol, 84(2), 265–272. https://doi.org/10.1016/j.jaad.2020.08.059
Patel, Sagar P., Raveena Khanna, Justin Choi, Kyle A. Williams, Youkyung S. Roh, Michael S. Hong, Nishadh H. Sutaria, Thomas Pritchard, Madan M. Kwatra, and Shawn G. Kwatra. “Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels.J Am Acad Dermatol 84, no. 2 (February 2021): 265–72. https://doi.org/10.1016/j.jaad.2020.08.059.
Patel SP, Khanna R, Choi J, Williams KA, Roh YS, Hong MS, et al. Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels. J Am Acad Dermatol. 2021 Feb;84(2):265–72.
Patel, Sagar P., et al. “Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels.J Am Acad Dermatol, vol. 84, no. 2, Feb. 2021, pp. 265–72. Pubmed, doi:10.1016/j.jaad.2020.08.059.
Patel SP, Khanna R, Choi J, Williams KA, Roh YS, Hong MS, Sutaria NH, Pritchard T, Kwatra MM, Kwatra SG. Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels. J Am Acad Dermatol. 2021 Feb;84(2):265–272.
Journal cover image

Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

February 2021

Volume

84

Issue

2

Start / End Page

265 / 272

Location

United States

Related Subject Headings

  • Sleep Wake Disorders
  • Risk Assessment
  • Quality of Life
  • Pruritus
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dermatology & Venereal Diseases
  • Cross-Sectional Studies