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Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin.

Publication ,  Journal Article
Itell, HL; Berenz, A; Mangan, RJ; Permar, SR; Kaufman, DA
Published in: Biochem Cell Biol
February 2021

Lactoferrin supplementation may help prevent infections in preterm infants, but the efficacy has varied with different doses and products. We assessed the absorption and excretion of bovine lactoferrin (bLF) in 31 infants receiving 100, 200, or 300 mg·kg-1·day-1 of enteral bLF for 30 days. bLF and human lactoferrin (hLF) in infant saliva, blood, urine, and stool, as well as expressed (EBM) or donor breast milk (DBM) that were collected (i) before the treatment was initiated, (ii) at study day 22, and (iii) one week after treatment cessation, were measured using ELISA. During treatment, bLF was absorbed from the gastrointestinal tract and detected in plasma, saliva, and urine, as well as excreted in stool. Levels of bLF in the saliva and stool began to decline within 12 h after dosing, and bLF was undetectable in all samples one week after treatment. The concentrations of hLF exceeded those of bLF across sample types and time-points. Infants receiving EBM demonstrated higher levels of hLF in the saliva and stool than those receiving DBM. Neither bLF nor hLF levels varied by patient characteristics, bLF dosage, or infection status. This is the first study demonstrating bLF absorption into the bloodstream and distribution to saliva and urine in preterm infants. Future studies should further explore LF pharmacokinetics because higher and more frequent dosing may improve the clinical benefit of LF supplementation.

Duke Scholars

Published In

Biochem Cell Biol

DOI

EISSN

1208-6002

Publication Date

February 2021

Volume

99

Issue

1

Start / End Page

25 / 34

Location

Canada

Related Subject Headings

  • Milk, Human
  • Lactoferrin
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Gastric Mucosa
  • Enzyme-Linked Immunosorbent Assay
  • Enteral Nutrition
  • Dietary Supplements
 

Citation

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Itell, H. L., Berenz, A., Mangan, R. J., Permar, S. R., & Kaufman, D. A. (2021). Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin. Biochem Cell Biol, 99(1), 25–34. https://doi.org/10.1139/bcb-2020-0238
Itell, Hannah L., Andrew Berenz, Riley J. Mangan, Sallie R. Permar, and David A. Kaufman. “Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin.Biochem Cell Biol 99, no. 1 (February 2021): 25–34. https://doi.org/10.1139/bcb-2020-0238.
Itell HL, Berenz A, Mangan RJ, Permar SR, Kaufman DA. Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin. Biochem Cell Biol. 2021 Feb;99(1):25–34.
Itell, Hannah L., et al. “Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin.Biochem Cell Biol, vol. 99, no. 1, Feb. 2021, pp. 25–34. Pubmed, doi:10.1139/bcb-2020-0238.
Itell HL, Berenz A, Mangan RJ, Permar SR, Kaufman DA. Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin. Biochem Cell Biol. 2021 Feb;99(1):25–34.

Published In

Biochem Cell Biol

DOI

EISSN

1208-6002

Publication Date

February 2021

Volume

99

Issue

1

Start / End Page

25 / 34

Location

Canada

Related Subject Headings

  • Milk, Human
  • Lactoferrin
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Gastric Mucosa
  • Enzyme-Linked Immunosorbent Assay
  • Enteral Nutrition
  • Dietary Supplements