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Massive transfusion: blood component ratios.

Publication ,  Journal Article
Lal, DS; Shaz, BH
Published in: Curr Opin Hematol
November 2013

PURPOSE OF REVIEW: This review will address recent developments in the transfusion management of massively transfused trauma patients, focusing on the use of fixed blood component ratios in massive transfusion protocols. RECENT FINDINGS: The majority of trauma centers have migrated from laboratory-based transfusion protocols to massive transfusion protocols with fixed blood component ratios. These protocols with red blood cell : plasma : platelet ratio of 1 : 1 : 1 are associated with improved survival in severely injured patients. However, alternate ratios have also demonstrated improved survival. Thus, the optimal ratio has not been determined. In addition, the use of medications, such as antifibrinolytics, and point of care testing, such as thromboelastography, are increasingly being used as part of massive transfusion protocols to adjust transfusion therapy and decrease bleeding. However, their optimal integration has yet to be determined. SUMMARY: Massive transfusion protocols with fixed ratios of red blood cells to plasma and platelets have improved survival in both civilian and military trauma patients. Continued studies of ratios as well as integration of other therapies and testing are ongoing in order to continue to improve patient outcome.

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Published In

Curr Opin Hematol

DOI

EISSN

1531-7048

Publication Date

November 2013

Volume

20

Issue

6

Start / End Page

521 / 525

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Immunology
  • Humans
  • Hemorrhagic Disorders
  • Clinical Protocols
  • Blood Component Transfusion
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Lal, D. S., & Shaz, B. H. (2013). Massive transfusion: blood component ratios. Curr Opin Hematol, 20(6), 521–525. https://doi.org/10.1097/MOH.0b013e3283653982
Lal, Devika S., and Beth H. Shaz. “Massive transfusion: blood component ratios.Curr Opin Hematol 20, no. 6 (November 2013): 521–25. https://doi.org/10.1097/MOH.0b013e3283653982.
Lal DS, Shaz BH. Massive transfusion: blood component ratios. Curr Opin Hematol. 2013 Nov;20(6):521–5.
Lal, Devika S., and Beth H. Shaz. “Massive transfusion: blood component ratios.Curr Opin Hematol, vol. 20, no. 6, Nov. 2013, pp. 521–25. Pubmed, doi:10.1097/MOH.0b013e3283653982.
Lal DS, Shaz BH. Massive transfusion: blood component ratios. Curr Opin Hematol. 2013 Nov;20(6):521–525.

Published In

Curr Opin Hematol

DOI

EISSN

1531-7048

Publication Date

November 2013

Volume

20

Issue

6

Start / End Page

521 / 525

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Immunology
  • Humans
  • Hemorrhagic Disorders
  • Clinical Protocols
  • Blood Component Transfusion
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology