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Transfusion Medicine and Hemostasis

Perinatal Transfusion Medicine

Publication ,  Chapter
Shaz, BH
December 1, 2009

This chapter discusses transfusion in perinatal medicine. Transfusion management of the pregnant woman and fetus requires special consideration and this chapter address the related issues: routine prenatal and neonatal transfusion testing in relationship to maternal alloimmunization, hemolytic diseases of the fetus and newborn (HDFN) and neonatal alloimmune thrombocytopenia (NAIT) as well as their treatments. HDFN occurs when maternal plasma contains an alloantibody against an antigen carried on the fetal RBCs. The severity of HDFN is influenced by the antibody titer and specificity, the immunoglobulin class and the number of antigenic sites on the RBC. Immune sensitization to RBC antigens occurs after fetomaternal hemorrhage (FMH) during pregnancy or delivery or through previous RBC transfusion. For prenatal testing of HDFN, if the pregnant women is D positive and has no alloantibodies, then no further testing is required. It the pregnant women is D negative and is not sensitized to the D antigen, then she should receive RhIg perinatally. © 2009 Elsevier Inc. All rights reserved.

Duke Scholars

DOI

ISBN

9780123744326

Publication Date

December 1, 2009

Start / End Page

241 / 249
 

Citation

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MLA
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Shaz, B. H. (2009). Perinatal Transfusion Medicine. In Transfusion Medicine and Hemostasis (pp. 241–249). https://doi.org/10.1016/B978-0-12-374432-6.00043-9
Shaz, B. H. “Perinatal Transfusion Medicine.” In Transfusion Medicine and Hemostasis, 241–49, 2009. https://doi.org/10.1016/B978-0-12-374432-6.00043-9.
Shaz BH. Perinatal Transfusion Medicine. In: Transfusion Medicine and Hemostasis. 2009. p. 241–9.
Shaz, B. H. “Perinatal Transfusion Medicine.” Transfusion Medicine and Hemostasis, 2009, pp. 241–49. Scopus, doi:10.1016/B978-0-12-374432-6.00043-9.
Shaz BH. Perinatal Transfusion Medicine. Transfusion Medicine and Hemostasis. 2009. p. 241–249.
Journal cover image

DOI

ISBN

9780123744326

Publication Date

December 1, 2009

Start / End Page

241 / 249