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Transfusion Medicine and Hemostasis

Therapeutic Plasma Exchange

Publication ,  Chapter
Shaz, BH
December 1, 2009

This chapter discusses therapeutic plasma exchange (TPE) also known as plasmapheresis. Therapeutic plasma exchange is a therapeutic procedure in which the blood of the patient is removed and passed through a medical device that separates out and removes the plasma from the other blood components, which are returned to the patient. TPE is mostly used for antibody removal from circulation as well as other molecules such as drugs and low-density lipoproteins. Moreover, it can be used to correct deficiencies of a plasma clotting factor when large volumes of plasma infusion would result in severe fluid overload in the patient. The volume of blood to be exchanged is based on a kinetic model of an isolated one-compartment intravascular space, which assumes that the component is neither synthesized nor degraded during the procedure and that it remains within the intravascular compartment. The time interval between plasma exchanges is generally chosen based on the need to allow the component of interest to re-equilibrate into the intravascular space and the need to minimize the risk of bleeding as a result of dilutional coagulopathy. © 2009 Elsevier Inc. All rights reserved.

Duke Scholars

DOI

ISBN

9780123744326

Publication Date

December 1, 2009

Start / End Page

383 / 397
 

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Shaz, B. H. (2009). Therapeutic Plasma Exchange. In Transfusion Medicine and Hemostasis (pp. 383–397). https://doi.org/10.1016/B978-0-12-374432-6.00068-3
Shaz, B. H. “Therapeutic Plasma Exchange.” In Transfusion Medicine and Hemostasis, 383–97, 2009. https://doi.org/10.1016/B978-0-12-374432-6.00068-3.
Shaz BH. Therapeutic Plasma Exchange. In: Transfusion Medicine and Hemostasis. 2009. p. 383–97.
Shaz, B. H. “Therapeutic Plasma Exchange.” Transfusion Medicine and Hemostasis, 2009, pp. 383–97. Scopus, doi:10.1016/B978-0-12-374432-6.00068-3.
Shaz BH. Therapeutic Plasma Exchange. Transfusion Medicine and Hemostasis. 2009. p. 383–397.
Journal cover image

DOI

ISBN

9780123744326

Publication Date

December 1, 2009

Start / End Page

383 / 397