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Transfusion Medicine and Hemostasis

Microchimerism

Publication ,  Chapter
Shaz, BH; Hillyer, CD
December 1, 2009

This chapter focuses on transfusion-associated microchimeism (TA-MC). Chimerism is the presence of more than one genetically distinct population of cells in a single organism that originated from more than one zygote and microchimerism occurs when the non-host cells represent only <5% of the cells of an individual and can be a consequence of pregnancy, organ transplantation and transfusion. Blood transfusion can result in a stable persistent minor population of allogeneic cells within the recipient and it is termed TA-MC. Transfusion-associated microchimerism is the presence of transfused donor leukocytes constituting up to 5% of the recipient's peripheral blood leukocytes, which can remain for long periods of time. For the diagnosis of TA-MC, it requires the selection of optimal genetic difference between donor and recipient DNA, and the capability to detect the small amount of donor DNA amongst a large amount of host DNA. A technique to detect TA-MC is real-time polymerase chain reaction (PCR) and a limitation to the testing techniques is the difficulty to detect TC-MC in the sample volume and sampling error. © 2009 Elsevier Inc. All rights reserved.

Duke Scholars

DOI

ISBN

9780123744326

Publication Date

December 1, 2009

Start / End Page

353 / 355
 

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Shaz, B. H., & Hillyer, C. D. (2009). Microchimerism. In Transfusion Medicine and Hemostasis (pp. 353–355). https://doi.org/10.1016/B978-0-12-374432-6.00063-4
Shaz, B. H., and C. D. Hillyer. “Microchimerism.” In Transfusion Medicine and Hemostasis, 353–55, 2009. https://doi.org/10.1016/B978-0-12-374432-6.00063-4.
Shaz BH, Hillyer CD. Microchimerism. In: Transfusion Medicine and Hemostasis. 2009. p. 353–5.
Shaz, B. H., and C. D. Hillyer. “Microchimerism.” Transfusion Medicine and Hemostasis, 2009, pp. 353–55. Scopus, doi:10.1016/B978-0-12-374432-6.00063-4.
Shaz BH, Hillyer CD. Microchimerism. Transfusion Medicine and Hemostasis. 2009. p. 353–355.
Journal cover image

DOI

ISBN

9780123744326

Publication Date

December 1, 2009

Start / End Page

353 / 355