NLRP1 - One NLR to guard them all.
Publication
, Journal Article
Lacey, CA; Miao, EA
Published in: EMBO J
July 1, 2019
Microbial pathogens can be detected by inflammasomes that induce inflammation and programmed cell death. Inflammasomes are sensors that survey cells for signs of compromise. One of these sensors, NLRP1, detects anthrax lethal toxin; however, the mechanism of NLRP1 activation has remained unknown. Here, Xu et al discover NLRP1 cleavage by lethal toxin induces the N-end rule, which targets NLRP1 for degradation. Surprisingly, the active inflammasome fragment escapes the proteasome and becomes an activate inflammasome itself.
Duke Scholars
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Published In
EMBO J
DOI
EISSN
1460-2075
Publication Date
July 1, 2019
Volume
38
Issue
13
Start / End Page
e102494
Location
England
Related Subject Headings
- Ubiquitin
- NLR Proteins
- Ligases
- Inflammasomes
- Humans
- Developmental Biology
- Apoptosis Regulatory Proteins
- Anthrax
- Adaptor Proteins, Signal Transducing
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lacey, C. A., & Miao, E. A. (2019). NLRP1 - One NLR to guard them all. EMBO J, 38(13), e102494. https://doi.org/10.15252/embj.2019102494
Lacey, Carolyn A., and Edward A. Miao. “NLRP1 - One NLR to guard them all.” EMBO J 38, no. 13 (July 1, 2019): e102494. https://doi.org/10.15252/embj.2019102494.
Lacey CA, Miao EA. NLRP1 - One NLR to guard them all. EMBO J. 2019 Jul 1;38(13):e102494.
Lacey, Carolyn A., and Edward A. Miao. “NLRP1 - One NLR to guard them all.” EMBO J, vol. 38, no. 13, July 2019, p. e102494. Pubmed, doi:10.15252/embj.2019102494.
Lacey CA, Miao EA. NLRP1 - One NLR to guard them all. EMBO J. 2019 Jul 1;38(13):e102494.
Published In
EMBO J
DOI
EISSN
1460-2075
Publication Date
July 1, 2019
Volume
38
Issue
13
Start / End Page
e102494
Location
England
Related Subject Headings
- Ubiquitin
- NLR Proteins
- Ligases
- Inflammasomes
- Humans
- Developmental Biology
- Apoptosis Regulatory Proteins
- Anthrax
- Adaptor Proteins, Signal Transducing
- 32 Biomedical and clinical sciences