Scholars@Duke publication: Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Publication , Journal Article

Chen, M-H; Raffield, LM; Mousas, A; Sakaue, S; Huffman, JE; Moscati, A; Trivedi, B; Jiang, T; Akbari, P; Vuckovic, D; Bao, EL; Zhong, X ...

Published in: Cell

September 3, 2020

Published version (DOI) Link to item

Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10-9, including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EUR meta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these blood phenotypes between populations. Altogether, our results for hematological traits highlight the value of a more global representation of populations in genetic studies.

Duke Scholars

Author Yongmei Liu Medicine, Cardiology

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Published In

Cell

DOI

10.1016/j.cell.2020.06.045

EISSN

1097-4172

Publication Date

September 3, 2020

Volume

182

Issue

Start / End Page

1198 / 1213.e14

Location

United States

Related Subject Headings

White People
Polymorphism, Single Nucleotide
Phenotype
Mutation, Missense
Interleukin-7
Humans
HEK293 Cells
Genome-Wide Association Study
Genetics
Developmental Biology

Citation

APA

Chicago

ICMJE

MLA

NLM

Chen, M.-H., Raffield, L. M., Mousas, A., Sakaue, S., Huffman, J. E., Moscati, A., … Lettre, G. (2020). Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell, 182(5), 1198-1213.e14. https://doi.org/10.1016/j.cell.2020.06.045

Chen, Ming-Huei, Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Arden Moscati, Bhavi Trivedi, et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182, no. 5 (September 3, 2020): 1198-1213.e14. https://doi.org/10.1016/j.cell.2020.06.045.

Chen M-H, Raffield LM, Mousas A, Sakaue S, Huffman JE, Moscati A, et al. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell. 2020 Sep 3;182(5):1198-1213.e14.

Chen, Ming-Huei, et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell, vol. 182, no. 5, Sept. 2020, pp. 1198-1213.e14. Pubmed, doi:10.1016/j.cell.2020.06.045.

Chen M-H, Raffield LM, Mousas A, Sakaue S, Huffman JE, Moscati A, Trivedi B, Jiang T, Akbari P, Vuckovic D, Bao EL, Zhong X, Manansala R, Laplante V, Chen M, Lo KS, Qian H, Lareau CA, Beaudoin M, Hunt KA, Akiyama M, Bartz TM, Ben-Shlomo Y, Beswick A, Bork-Jensen J, Bottinger EP, Brody JA, van Rooij FJA, Chitrala K, Cho K, Choquet H, Correa A, Danesh J, Di Angelantonio E, Dimou N, Ding J, Elliott P, Esko T, Evans MK, Floyd JS, Broer L, Grarup N, Guo MH, Greinacher A, Haessler J, Hansen T, Howson JMM, Huang QQ, Huang W, Jorgenson E, Kacprowski T, Kähönen M, Kamatani Y, Kanai M, Karthikeyan S, Koskeridis F, Lange LA, Lehtimäki T, Lerch MM, Linneberg A, Liu Y, Lyytikäinen L-P, Manichaikul A, Martin HC, Matsuda K, Mohlke KL, Mononen N, Murakami Y, Nadkarni GN, Nauck M, Nikus K, Ouwehand WH, Pankratz N, Pedersen O, Preuss M, Psaty BM, Raitakari OT, Roberts DJ, Rich SS, Rodriguez BAT, Rosen JD, Rotter JI, Schubert P, Spracklen CN, Surendran P, Tang H, Tardif J-C, Trembath RC, Ghanbari M, Völker U, Völzke H, Watkins NA, Zonderman AB, VA Million Veteran Program, Wilson PWF, Li Y, Butterworth AS, Gauchat J-F, Chiang CWK, Li B, Loos RJF, Astle WJ, Evangelou E, van Heel DA, Sankaran VG, Okada Y, Soranzo N, Johnson AD, Reiner AP, Auer PL, Lettre G. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations. Cell. 2020 Sep 3;182(5):1198-1213.e14.

Published In

Cell

DOI

10.1016/j.cell.2020.06.045

EISSN

1097-4172

Publication Date

September 3, 2020

Volume

182

Issue

Start / End Page

1198 / 1213.e14

Location

United States

Related Subject Headings

White People
Polymorphism, Single Nucleotide
Phenotype
Mutation, Missense
Interleukin-7
Humans
HEK293 Cells
Genome-Wide Association Study
Genetics
Developmental Biology