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Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients.

Publication ,  Journal Article
Seheult, JN; Dunbar, NM; Hess, JR; Tuott, EE; Bahmanyar, M; Campbell, J; Fontaine, M; Khan, J; Ko, A; Mi, J; Murphy, MF; Nykoluk, T; Shih, A ...
Published in: Transfusion
November 2020

BACKGROUND: This study investigated the effect on mortality of transfusing ABO-incompatible plasma from all sources during trauma resuscitation. METHODS: Demographic, transfusion, and survival data were retrospectively extracted on civilian trauma patients. Patients were divided by receipt of any quantity of ABO-incompatible plasma from any blood product (incompatible group) or receipt of solely ABO-compatible plasma (compatible group). The primary outcome was 30-day mortality, while other outcomes included 6- and 24-hour mortality. Mixed-effects logistic regression was used to model the effect of various predictor variables, including receipt of incompatible plasma, on mortality outcomes. RESULTS: Nine hospitals contributed data on a total of 2618 trauma patients. There were 1282 patients in the incompatible group and 1336 patients in the compatible group. In both the unadjusted and adjusted models, the 6-hour, 24-hour, and 30-day mortality rates were not significantly different between these groups. The patients in the incompatible group were then divided into high volume (>342 mL) and low volume (≤342 mL) incompatible plasma recipients. In the adjusted model, the high-volume group had higher 24-hour mortality when the Trauma Injury Severity Score survival prediction was >50%. Mortality at 6 hours and 30 days was not higher in this model. The low-volume group did not have increased mortality at any of the time points in this adjusted model. CONCLUSION: The transfusion of incompatible plasma in civilian trauma resuscitation does not lead to higher 30-day mortality. The finding of higher mortality in a select group of recipients in the secondary analysis warrants further study.

Duke Scholars

Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

November 2020

Volume

60

Issue

11

Start / End Page

2517 / 2528

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Trauma Severity Indices
  • Survival Rate
  • Retrospective Studies
  • Resuscitation
  • Models, Biological
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Seheult, J. N., Dunbar, N. M., Hess, J. R., Tuott, E. E., Bahmanyar, M., Campbell, J., … Biomedical Excellence for Safer Transfusion (BEST) collaborative, . (2020). Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients. Transfusion, 60(11), 2517–2528. https://doi.org/10.1111/trf.16008
Seheult, Jansen N., Nancy M. Dunbar, John R. Hess, Erin E. Tuott, Mohammad Bahmanyar, Jessica Campbell, Magali Fontaine, et al. “Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients.Transfusion 60, no. 11 (November 2020): 2517–28. https://doi.org/10.1111/trf.16008.
Seheult JN, Dunbar NM, Hess JR, Tuott EE, Bahmanyar M, Campbell J, et al. Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients. Transfusion. 2020 Nov;60(11):2517–28.
Seheult, Jansen N., et al. “Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients.Transfusion, vol. 60, no. 11, Nov. 2020, pp. 2517–28. Pubmed, doi:10.1111/trf.16008.
Seheult JN, Dunbar NM, Hess JR, Tuott EE, Bahmanyar M, Campbell J, Fontaine M, Khan J, Ko A, Mi J, Murphy MF, Nykoluk T, Poisson J, Raval JS, Shih A, Sperry JL, Staves J, Wong M, Yan MTS, Ziman A, Yazer MH, Biomedical Excellence for Safer Transfusion (BEST) collaborative. Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients. Transfusion. 2020 Nov;60(11):2517–2528.
Journal cover image

Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

November 2020

Volume

60

Issue

11

Start / End Page

2517 / 2528

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Trauma Severity Indices
  • Survival Rate
  • Retrospective Studies
  • Resuscitation
  • Models, Biological
  • Middle Aged
  • Male
  • Humans
  • Female