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Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation.

Publication ,  Journal Article
Hijazi, Z; Granger, CB; Hohnloser, SH; Westerbergh, J; Lindbäck, J; Alexander, JH; Keltai, M; Parkhomenko, A; López-Sendón, JL; Lopes, RD ...
Published in: J Am Heart Assoc
September 15, 2020

Background We compared different methods of estimated glomerular filtration rate (eGFR) and their association with cardiovascular death and major bleeding in 14 980 patients with atrial fibrillation in the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial. Methods and Results eGFR was calculated using equations based on creatinine (Cockcroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) and/or cystatin C (CKD-EPICysC and CKD-EPICysC+Creatinine). These 5 eGFR equations, as well as the individual variables that are used in these equations, were assessed for correlation and discriminatory ability for cardiovascular death and major bleeding. The median age was 70.0 years, and 35.6% were women. The median eGFR was highest with Cockcroft-Gault (74.1 mL/min) and CKD-EPICysC (74.2 mL/min), and lowest with Modification of Diet in Renal Disease (66.5 mL/min). Correlation between methods ranged from 0.49 (Cockroft-Gault and CKD-EPICysC) to 0.99 (Modification of Diet in Renal Disease and CKD-EPI). Among the eGFR equations, those based on cystatin C yielded the highest C indices for cardiovascular death and major bleeding: 0.628 (CKD-EPICysC) and 0.612 (CKD-EPICysC+Creatinine), respectively. A model based on the variables within the different eGFR equations (age, sex, weight, creatinine, and cystatin C) yielded the highest discriminatory value for both outcomes, with a C index of 0.673 and 0.656, respectively. Conclusions In patients with atrial fibrillation on anticoagulation, correlation between eGFR calculated using different methods varied substantially. Cystatin C-based eGFRs seem to provide the most robust information for predicting death and bleeding. A model based on the individual variables within the eGFR equations, however, provided the highest discriminatory value. Our findings may help refine risk stratification in patients with atrial fibrillation and define how renal function should be determined in future atrial fibrillation studies. Registration URL: https://www.clini​caltr​ials.gov; Unique identifier: NCT00412984.

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Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

September 15, 2020

Volume

9

Issue

18

Start / End Page

e017155

Location

England

Related Subject Headings

  • Risk Assessment
  • Male
  • Kidney
  • Humans
  • Hemorrhage
  • Glomerular Filtration Rate
  • Female
  • Cardiovascular Diseases
  • Atrial Fibrillation
  • Anticoagulants
 

Citation

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Hijazi, Z., Granger, C. B., Hohnloser, S. H., Westerbergh, J., Lindbäck, J., Alexander, J. H., … Wallentin, L. (2020). Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation. J Am Heart Assoc, 9(18), e017155. https://doi.org/10.1161/JAHA.120.017155
Hijazi, Ziad, Christopher B. Granger, Stefan H. Hohnloser, Johan Westerbergh, Johan Lindbäck, John H. Alexander, Matyas Keltai, et al. “Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation.J Am Heart Assoc 9, no. 18 (September 15, 2020): e017155. https://doi.org/10.1161/JAHA.120.017155.
Hijazi Z, Granger CB, Hohnloser SH, Westerbergh J, Lindbäck J, Alexander JH, et al. Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation. J Am Heart Assoc. 2020 Sep 15;9(18):e017155.
Hijazi, Ziad, et al. “Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation.J Am Heart Assoc, vol. 9, no. 18, Sept. 2020, p. e017155. Pubmed, doi:10.1161/JAHA.120.017155.
Hijazi Z, Granger CB, Hohnloser SH, Westerbergh J, Lindbäck J, Alexander JH, Keltai M, Parkhomenko A, López-Sendón JL, Lopes RD, Siegbahn A, Wallentin L. Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation. J Am Heart Assoc. 2020 Sep 15;9(18):e017155.
Journal cover image

Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

September 15, 2020

Volume

9

Issue

18

Start / End Page

e017155

Location

England

Related Subject Headings

  • Risk Assessment
  • Male
  • Kidney
  • Humans
  • Hemorrhage
  • Glomerular Filtration Rate
  • Female
  • Cardiovascular Diseases
  • Atrial Fibrillation
  • Anticoagulants