Skip to main content

Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.

Publication ,  Journal Article
Smith, PJ; Mabe, SM; Sherwood, A; Doraiswamy, PM; Welsh-Bohmer, KA; Burke, JR; Kraus, WE; Lin, P-H; Browndyke, JN; Babyak, MA; Hinderliter, AL ...
Published in: J Alzheimers Dis
2020

BACKGROUND: Previous studies have demonstrated that aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet can improve neurocognition. However, the mechanisms by which lifestyle improves neurocognition have not been widely studied. We examined the associations between changes in metabolic, neurotrophic, and inflammatory biomarkers with executive functioning among participants from the Exercise and Nutritional Interventions for Neurocognitive Health Enhancement (ENLIGHTEN) trial. OBJECTIVE: To examine the association between changes in metabolic function and neurocognition among older adults with cognitive impairment, but without dementia (CIND) participating in a comprehensive lifestyle intervention. METHODS: ENLIGHTEN participants were randomized using a 2×2 factorial design to receive AE, DASH, both AE+DASH, or a health education control condition (HE) for six months. Metabolic biomarkers included insulin resistance (homeostatic model assessment [HOMA-IR]), leptin, and insulin-like growth factor (IGF-1); neurotrophic biomarkers included brain derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF); and inflammatory biomarkers included interleukin-6 (IL-6) and C-Reactive Protein (CRP). RESULTS: Participants included 132 sedentary older adults (mean age = 65 [SD = 7]) with CIND. Results demonstrated that both AE (d = 0.48, p = 0.015) and DASH improved metabolic function (d = 0.37, p = 0.039), without comparable improvements in neurotrophic or inflammatory biomarkers. Greater improvements in metabolic function, including reduced HOMA-IR (B = -2.3 [-4.3, -0.2], p = 0.033) and increased IGF-1 (B = 3.4 [1.2, 5.7], p = 0.004), associated with increases in Executive Function. CONCLUSION: Changes in neurocognition after lifestyle modification are associated with improved metabolic function.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2020

Volume

77

Issue

4

Start / End Page

1793 / 1803

Location

Netherlands

Related Subject Headings

  • Sedentary Behavior
  • Risk Reduction Behavior
  • Nutritional Status
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Status and Dementia Tests
  • Male
  • Humans
  • Female
  • Exercise Test
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Smith, P. J., Mabe, S. M., Sherwood, A., Doraiswamy, P. M., Welsh-Bohmer, K. A., Burke, J. R., … Blumenthal, J. A. (2020). Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial. J Alzheimers Dis, 77(4), 1793–1803. https://doi.org/10.3233/JAD-200374
Smith, Patrick J., Stephanie M. Mabe, Andrew Sherwood, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, James R. Burke, William E. Kraus, et al. “Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.J Alzheimers Dis 77, no. 4 (2020): 1793–1803. https://doi.org/10.3233/JAD-200374.
Smith PJ, Mabe SM, Sherwood A, Doraiswamy PM, Welsh-Bohmer KA, Burke JR, et al. Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial. J Alzheimers Dis. 2020;77(4):1793–803.
Smith, Patrick J., et al. “Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.J Alzheimers Dis, vol. 77, no. 4, 2020, pp. 1793–803. Pubmed, doi:10.3233/JAD-200374.
Smith PJ, Mabe SM, Sherwood A, Doraiswamy PM, Welsh-Bohmer KA, Burke JR, Kraus WE, Lin P-H, Browndyke JN, Babyak MA, Hinderliter AL, Blumenthal JA. Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial. J Alzheimers Dis. 2020;77(4):1793–1803.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2020

Volume

77

Issue

4

Start / End Page

1793 / 1803

Location

Netherlands

Related Subject Headings

  • Sedentary Behavior
  • Risk Reduction Behavior
  • Nutritional Status
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Status and Dementia Tests
  • Male
  • Humans
  • Female
  • Exercise Test