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Lymphoid enhancer binding factor 1 (LEF1) expression is significantly higher in Hodgkin lymphoma associated with Richter syndrome relative to de novo classic Hodgkin lymphoma.

Publication ,  Journal Article
Lyapichev, KA; Sakhdari, A; Khoury, JD; O'Malley, DP; El Hussein, S; Yin, CC; Patel, KP; Thakral, B; Young, KH; Medeiros, LJ; Konoplev, S
Published in: Ann Diagn Pathol
December 2020

Lymphoid enhancer binding factor 1 (LEF1) is consistently upregulated in chronic lymphocytic leukemia (CLL) and in a subset of large B cell lymphoma. Knowledge of LEF1 expression in Hodgkin lymphoma is limited. In this study, we used immunohistochemistry to survey LEF1 expression in various subsets of Hodgkin lymphoma, de novo classic Hodgkin lymphoma (CHL) (n = 43), Hodgkin lymphoma associated with Richter syndrome (HL-RS) (n = 20), and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) (n = 9). LEF1 expression was significantly higher in HL-RS compared with de novo CHL (12/20, 60% vs. 12/43, 28%; p = 0.0248). Only a single case (1/9; 11%) of NLPHL showed LEF1 expression. Epstein-Barr virus encoded RNA (EBER) was detected in 17 (40%) cases of de novo CHL and 14 (70%) HL-RS. Notably, we identified a correlation between LEF1 expression and EBER positivity (p = 0.0488). We concluded that LEF1 is commonly positive in CHL but not in NLPHL, and such a distinction may be helpful in this differential diagnosis. The higher frequency of LEF1 upregulation in HL-RS relative to de novo CHL suggests that these neoplasms might have different underlying pathogenic mechanisms and warrants further investigation.

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Published In

Ann Diagn Pathol

DOI

EISSN

1532-8198

Publication Date

December 2020

Volume

49

Start / End Page

151636

Location

United States

Related Subject Headings

  • Young Adult
  • Pathology
  • Middle Aged
  • Male
  • Lymphoid Enhancer-Binding Factor 1
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Humans
  • Hodgkin Disease
  • Female
  • Child
 

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Lyapichev, K. A., Sakhdari, A., Khoury, J. D., O’Malley, D. P., El Hussein, S., Yin, C. C., … Konoplev, S. (2020). Lymphoid enhancer binding factor 1 (LEF1) expression is significantly higher in Hodgkin lymphoma associated with Richter syndrome relative to de novo classic Hodgkin lymphoma. Ann Diagn Pathol, 49, 151636. https://doi.org/10.1016/j.anndiagpath.2020.151636
Lyapichev, Kirill A., Ali Sakhdari, Joseph D. Khoury, Dennis P. O’Malley, Siba El Hussein, Cameron C. Yin, Keyur P. Patel, et al. “Lymphoid enhancer binding factor 1 (LEF1) expression is significantly higher in Hodgkin lymphoma associated with Richter syndrome relative to de novo classic Hodgkin lymphoma.Ann Diagn Pathol 49 (December 2020): 151636. https://doi.org/10.1016/j.anndiagpath.2020.151636.
Lyapichev KA, Sakhdari A, Khoury JD, O’Malley DP, El Hussein S, Yin CC, et al. Lymphoid enhancer binding factor 1 (LEF1) expression is significantly higher in Hodgkin lymphoma associated with Richter syndrome relative to de novo classic Hodgkin lymphoma. Ann Diagn Pathol. 2020 Dec;49:151636.
Lyapichev, Kirill A., et al. “Lymphoid enhancer binding factor 1 (LEF1) expression is significantly higher in Hodgkin lymphoma associated with Richter syndrome relative to de novo classic Hodgkin lymphoma.Ann Diagn Pathol, vol. 49, Dec. 2020, p. 151636. Pubmed, doi:10.1016/j.anndiagpath.2020.151636.
Lyapichev KA, Sakhdari A, Khoury JD, O’Malley DP, El Hussein S, Yin CC, Patel KP, Thakral B, Young KH, Medeiros LJ, Konoplev S. Lymphoid enhancer binding factor 1 (LEF1) expression is significantly higher in Hodgkin lymphoma associated with Richter syndrome relative to de novo classic Hodgkin lymphoma. Ann Diagn Pathol. 2020 Dec;49:151636.
Journal cover image

Published In

Ann Diagn Pathol

DOI

EISSN

1532-8198

Publication Date

December 2020

Volume

49

Start / End Page

151636

Location

United States

Related Subject Headings

  • Young Adult
  • Pathology
  • Middle Aged
  • Male
  • Lymphoid Enhancer-Binding Factor 1
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Humans
  • Hodgkin Disease
  • Female
  • Child