Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.
Publication
, Journal Article
Otsuki, K; Li, W; Miura, K; Asada, Y; Huang, L; Chen, C-H; Lee, K-H; Koike, K
Published in: Journal of natural products
November 2020
Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Journal of natural products
DOI
EISSN
1520-6025
ISSN
0163-3864
Publication Date
November 2020
Volume
83
Issue
11
Start / End Page
3270 / 3277
Related Subject Headings
- Structure-Activity Relationship
- Spectrum Analysis
- Molecular Structure
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- HIV
- Diterpenes
- Daphne
- Cell Line
- Anti-HIV Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Otsuki, K., Li, W., Miura, K., Asada, Y., Huang, L., Chen, C.-H., … Koike, K. (2020). Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora. Journal of Natural Products, 83(11), 3270–3277. https://doi.org/10.1021/acs.jnatprod.0c00540
Otsuki, Kouharu, Wei Li, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.” Journal of Natural Products 83, no. 11 (November 2020): 3270–77. https://doi.org/10.1021/acs.jnatprod.0c00540.
Otsuki K, Li W, Miura K, Asada Y, Huang L, Chen C-H, et al. Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora. Journal of natural products. 2020 Nov;83(11):3270–7.
Otsuki, Kouharu, et al. “Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.” Journal of Natural Products, vol. 83, no. 11, Nov. 2020, pp. 3270–77. Epmc, doi:10.1021/acs.jnatprod.0c00540.
Otsuki K, Li W, Miura K, Asada Y, Huang L, Chen C-H, Lee K-H, Koike K. Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora. Journal of natural products. 2020 Nov;83(11):3270–3277.
Published In
Journal of natural products
DOI
EISSN
1520-6025
ISSN
0163-3864
Publication Date
November 2020
Volume
83
Issue
11
Start / End Page
3270 / 3277
Related Subject Headings
- Structure-Activity Relationship
- Spectrum Analysis
- Molecular Structure
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- HIV
- Diterpenes
- Daphne
- Cell Line
- Anti-HIV Agents