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Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies.

Publication ,  Journal Article
Frankhauser, DE; Jovanovic-Talisman, T; Lai, L; Yee, LD; Wang, LV; Mahabal, A; Geradts, J; Rockne, RC; Tomsic, J; Jones, V; Sistrunk, C ...
Published in: WIREs Mech Dis
March 2021

Over 90% of breast cancer is cured; yet there remain highly aggressive breast cancers that develop rapidly and are extremely difficult to treat, much less prevent. Breast cancers that rapidly develop between breast image screening are called "interval cancers." The efforts of our team focus on identifying multiscale integrated strategies to identify biologically aggressive precancerous breast lesions. Our goal is to identify spatiotemporal changes that occur prior to development of interval breast cancers. To accomplish this requires integration of new technology. Our team has the ability to perform single cell in situ transcriptional profiling, noncontrast biological imaging, mathematical analysis, and nanoscale evaluation of receptor organization and signaling. These technological innovations allow us to start to identify multidimensional spatial and temporal relationships that drive the transition from biologically aggressive precancer to biologically aggressive interval breast cancer. This article is categorized under: Cancer > Computational Models Cancer > Molecular and Cellular Physiology Cancer > Genetics/Genomics/Epigenetics.

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Published In

WIREs Mech Dis

DOI

EISSN

2692-9368

Publication Date

March 2021

Volume

13

Issue

2

Start / End Page

e1506

Location

United States

Related Subject Headings

  • Precancerous Conditions
  • Mammography
  • Humans
  • Female
  • Breast Neoplasms
  • Biopsy
  • Biology
 

Citation

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Frankhauser, D. E., Jovanovic-Talisman, T., Lai, L., Yee, L. D., Wang, L. V., Mahabal, A., … Seewaldt, V. L. (2021). Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies. WIREs Mech Dis, 13(2), e1506. https://doi.org/10.1002/wsbm.1506
Frankhauser, David E., Tijana Jovanovic-Talisman, Lily Lai, Lisa D. Yee, Lihong V. Wang, Ashish Mahabal, Joseph Geradts, et al. “Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies.WIREs Mech Dis 13, no. 2 (March 2021): e1506. https://doi.org/10.1002/wsbm.1506.
Frankhauser DE, Jovanovic-Talisman T, Lai L, Yee LD, Wang LV, Mahabal A, et al. Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies. WIREs Mech Dis. 2021 Mar;13(2):e1506.
Frankhauser, David E., et al. “Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies.WIREs Mech Dis, vol. 13, no. 2, Mar. 2021, p. e1506. Pubmed, doi:10.1002/wsbm.1506.
Frankhauser DE, Jovanovic-Talisman T, Lai L, Yee LD, Wang LV, Mahabal A, Geradts J, Rockne RC, Tomsic J, Jones V, Sistrunk C, Miranda-Carboni G, Dietze EC, Erhunmwunsee L, Hyslop T, Seewaldt VL. Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies. WIREs Mech Dis. 2021 Mar;13(2):e1506.

Published In

WIREs Mech Dis

DOI

EISSN

2692-9368

Publication Date

March 2021

Volume

13

Issue

2

Start / End Page

e1506

Location

United States

Related Subject Headings

  • Precancerous Conditions
  • Mammography
  • Humans
  • Female
  • Breast Neoplasms
  • Biopsy
  • Biology