Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.
Publication
, Journal Article
Wang, Q; Li, Y; Zheng, L; Huang, X; Wang, Y; Chen, C-H; Cheng, Y-Y; Morris-Natschke, SL; Lee, K-H
Published in: ACS Med Chem Lett
November 12, 2020
Novel betulinic/betulonic acid-nucleoside hybrids were synthesized as possible new anti-HIV agents. Among the synthesized hybrids, two compounds were highly effective against HIV. Compared with AZT and DSB, compounds 10a (IC50 = 0.0078 μM, CC50 = 9.6 μM) and 10b (IC50 = 0.020 μM, CC50 = 23.8 μM) showed more potent or equipotent, respectively, anti-HIV activity but displayed lower cytotoxicity.
Duke Scholars
Published In
ACS Med Chem Lett
DOI
ISSN
1948-5875
Publication Date
November 12, 2020
Volume
11
Issue
11
Start / End Page
2290 / 2293
Location
United States
Related Subject Headings
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Wang, Q., Li, Y., Zheng, L., Huang, X., Wang, Y., Chen, C.-H., … Lee, K.-H. (2020). Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity. ACS Med Chem Lett, 11(11), 2290–2293. https://doi.org/10.1021/acsmedchemlett.0c00414
Wang, Qiang, Yujiang Li, Liyun Zheng, Xiaowan Huang, Yanli Wang, Chin-Ho Chen, Yung-Yi Cheng, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.” ACS Med Chem Lett 11, no. 11 (November 12, 2020): 2290–93. https://doi.org/10.1021/acsmedchemlett.0c00414.
Wang Q, Li Y, Zheng L, Huang X, Wang Y, Chen C-H, et al. Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity. ACS Med Chem Lett. 2020 Nov 12;11(11):2290–3.
Wang, Qiang, et al. “Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.” ACS Med Chem Lett, vol. 11, no. 11, Nov. 2020, pp. 2290–93. Pubmed, doi:10.1021/acsmedchemlett.0c00414.
Wang Q, Li Y, Zheng L, Huang X, Wang Y, Chen C-H, Cheng Y-Y, Morris-Natschke SL, Lee K-H. Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity. ACS Med Chem Lett. 2020 Nov 12;11(11):2290–2293.
Published In
ACS Med Chem Lett
DOI
ISSN
1948-5875
Publication Date
November 12, 2020
Volume
11
Issue
11
Start / End Page
2290 / 2293
Location
United States
Related Subject Headings
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry