RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.
A major challenge in neurobiology in the 21st century is to understand how the brain adapts with experience. Activity-dependent gene expression is integral to the synaptic plasticity underlying learning and memory; however, this process cannot be explained by a simple linear trajectory of transcription to translation within a specific neuronal population. Many other regulatory mechanisms can influence RNA metabolism and the capacity of neurons to adapt. In particular, the RNA modification N6-methyladenosine (m6A) has recently been shown to regulate RNA processing through alternative splicing, RNA stability, and translation. Here, we discuss the emerging idea that m6A could also coordinate the transport, localization, and local translation of key mRNAs in learning and memory and expand on the notion of dynamic functional RNA states in the brain.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- RNA
- Neurons
- Neuronal Plasticity
- Neurology & Neurosurgery
- Humans
- Brain
- Adenosine
- 5203 Clinical and health psychology
- 5202 Biological psychology
- 3209 Neurosciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- RNA
- Neurons
- Neuronal Plasticity
- Neurology & Neurosurgery
- Humans
- Brain
- Adenosine
- 5203 Clinical and health psychology
- 5202 Biological psychology
- 3209 Neurosciences