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Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation.

Publication ,  Journal Article
Piccini, JP; Todd, DM; Massaro, T; Lougee, A; Haeusler, KG; Blank, B; de Bono, JP; Callans, DJ; Elvan, A; Fetsch, T; Van Gelder, I; Hansen, J ...
Published in: Heart
December 2020

OBJECTIVE: To investigate changes in quality of life (QoL), cognition and functional status according to arrhythmia recurrence after atrial fibrillation (AF) ablation. METHODS: We compared QoL, cognition and functional status in patients with recurrent atrial tachycardia (AT)/AF versus those without recurrent AT/AF in the AXAFA-AFNET 5 clinical trial. We also sought to identify factors associated with improvement in QoL and functional status following AF ablation by overall change scores with and without analysis of covariance (ANCOVA). RESULTS: Among 518 patients who underwent AF ablation, 154 (29.7%) experienced recurrent AT/AF at 3 months. Patients with recurrent AT/AF had higher mean CHA2DS2-VASc scores (2.8 vs 2.3, p<0.001) and more persistent forms of AF (51 vs 39%, p=0.012). Median changes in the SF-12 physical (3 (25th, 75th: -1, 8) vs 1 (-5, 8), p=0.026) and mental scores (2 (-3, 9) vs 0 (-4, 5), p=0.004), EQ-5D (0 (0,2) vs 0 (-0.1, 0.1), p=0.027) and Karnofsky functional status scores (10 (0, 10) vs 0 (0, 10), p=0.001) were more favourable in patients without recurrent AT/AF. In the overall cohort, the proportion with at least mild cognitive impairment (Montreal Cognitive Assessment <26) declined from 30.3% (n=157) at baseline to 21.8% (n=113) at follow-up. ANCOVA identified greater improvement in Karnofsky functional status (p<0.001) but not SF-12 physical (p=0.238) or mental scores (p=0.065) in those without recurrent AT/AF compared with patients with recurrent AT/AF. CONCLUSIONS: Patients without recurrent AT/AF appear to experience greater improvement in functional status but similar QoL as those with recurrent AT/AF after AF ablation.

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Published In

Heart

DOI

EISSN

1468-201X

Publication Date

December 2020

Volume

106

Issue

24

Start / End Page

1919 / 1926

Location

England

Related Subject Headings

  • Treatment Outcome
  • Single-Blind Method
  • Risk Factors
  • Recurrence
  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Functional Status
 

Citation

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Piccini, J. P., Todd, D. M., Massaro, T., Lougee, A., Haeusler, K. G., Blank, B., … Kirchhof, P. (2020). Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation. Heart, 106(24), 1919–1926. https://doi.org/10.1136/heartjnl-2020-316612
Piccini, Jonathan P., Derick M. Todd, Tyler Massaro, Aimee Lougee, Karl Georg Haeusler, Benjamin Blank, Joseph Paul de Bono, et al. “Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation.Heart 106, no. 24 (December 2020): 1919–26. https://doi.org/10.1136/heartjnl-2020-316612.
Piccini JP, Todd DM, Massaro T, Lougee A, Haeusler KG, Blank B, et al. Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation. Heart. 2020 Dec;106(24):1919–26.
Piccini, Jonathan P., et al. “Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation.Heart, vol. 106, no. 24, Dec. 2020, pp. 1919–26. Pubmed, doi:10.1136/heartjnl-2020-316612.
Piccini JP, Todd DM, Massaro T, Lougee A, Haeusler KG, Blank B, de Bono JP, Callans DJ, Elvan A, Fetsch T, Van Gelder I, Gentlesk P, Grimaldi M, Hansen J, Hindricks G, Al-Khalidi H, Mont L, Nielsen JC, Noelker G, De Potter T, Scherr D, Schotten U, Themistoclakis S, Vijgen J, Di Biase L, Kirchhof P. Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation. Heart. 2020 Dec;106(24):1919–1926.

Published In

Heart

DOI

EISSN

1468-201X

Publication Date

December 2020

Volume

106

Issue

24

Start / End Page

1919 / 1926

Location

England

Related Subject Headings

  • Treatment Outcome
  • Single-Blind Method
  • Risk Factors
  • Recurrence
  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Functional Status