Spliceosomal immunophilins.
Publication
, Journal Article
Mesa, A; Somarelli, JA; Herrera, RJ
Published in: FEBS Lett
July 9, 2008
The spliceosome is a dynamic, macromolecular complex, which removes non-protein-coding introns from pre-mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine-rich small nuclear RNAs (snRNAs) as well as over 300 proteins. In humans, several of the known proteinaceous splicing factors are members of the immunophilin superfamily. Immunophilins are peptidyl-prolyl cis-trans isomerases that catalyze the conversion of proteins from cis to trans at Xaa-Pro bonds. Our review of the data indicates that some members of this protein family are activators of spliceosomal proteins by way of folding and transport.
Duke Scholars
Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
July 9, 2008
Volume
582
Issue
16
Start / End Page
2345 / 2351
Location
England
Related Subject Headings
- Spliceosomes
- Ribonucleoproteins, Small Nuclear
- RNA-Binding Proteins
- RNA Splicing
- Immunophilins
- Humans
- Fungal Proteins
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 0603 Evolutionary Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Mesa, A., Somarelli, J. A., & Herrera, R. J. (2008). Spliceosomal immunophilins. FEBS Lett, 582(16), 2345–2351. https://doi.org/10.1016/j.febslet.2008.06.006
Mesa, Annia, Jason A. Somarelli, and Rene J. Herrera. “Spliceosomal immunophilins.” FEBS Lett 582, no. 16 (July 9, 2008): 2345–51. https://doi.org/10.1016/j.febslet.2008.06.006.
Mesa A, Somarelli JA, Herrera RJ. Spliceosomal immunophilins. FEBS Lett. 2008 Jul 9;582(16):2345–51.
Mesa, Annia, et al. “Spliceosomal immunophilins.” FEBS Lett, vol. 582, no. 16, July 2008, pp. 2345–51. Pubmed, doi:10.1016/j.febslet.2008.06.006.
Mesa A, Somarelli JA, Herrera RJ. Spliceosomal immunophilins. FEBS Lett. 2008 Jul 9;582(16):2345–2351.
Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
July 9, 2008
Volume
582
Issue
16
Start / End Page
2345 / 2351
Location
England
Related Subject Headings
- Spliceosomes
- Ribonucleoproteins, Small Nuclear
- RNA-Binding Proteins
- RNA Splicing
- Immunophilins
- Humans
- Fungal Proteins
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 0603 Evolutionary Biology