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Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors.

Publication ,  Journal Article
Ramkissoon, LA; Pegram, W; Haberberger, J; Danziger, N; Lesser, G; Strowd, R; Dahiya, S; Cummings, TJ; Bi, WL; Abedalthagafi, M; Sathyan, P ...
Published in: Front Neurol
2020

Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished through invasive neurosurgical procedures, which restricts the number of patients to those who can safely undergo a surgical procedure, and for which such interventions will add meaningful value to the care of the patient. In this review we discuss the potential of analyzing cell free DNA shed from tumor cells that is contained within the cerebrospinal fluid (CSF) as a sensitive and minimally invasive method to detect and characterize primary and metastatic tumors in the CNS.

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Published In

Front Neurol

DOI

ISSN

1664-2295

Publication Date

2020

Volume

11

Start / End Page

544680

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Ramkissoon, L. A., Pegram, W., Haberberger, J., Danziger, N., Lesser, G., Strowd, R., … Ramkissoon, S. H. (2020). Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors. Front Neurol, 11, 544680. https://doi.org/10.3389/fneur.2020.544680
Ramkissoon, Lori A., Worthy Pegram, James Haberberger, Natalie Danziger, Glenn Lesser, Roy Strowd, Sonika Dahiya, et al. “Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors.Front Neurol 11 (2020): 544680. https://doi.org/10.3389/fneur.2020.544680.
Ramkissoon LA, Pegram W, Haberberger J, Danziger N, Lesser G, Strowd R, et al. Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors. Front Neurol. 2020;11:544680.
Ramkissoon, Lori A., et al. “Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors.Front Neurol, vol. 11, 2020, p. 544680. Pubmed, doi:10.3389/fneur.2020.544680.
Ramkissoon LA, Pegram W, Haberberger J, Danziger N, Lesser G, Strowd R, Dahiya S, Cummings TJ, Bi WL, Abedalthagafi M, Sathyan P, McGregor K, Reddy P, Severson E, Williams E, Lin D, Edgerly C, Huang RSP, Hemmerich A, Creeden J, Brown C, Venstrom J, Hegde P, Ross JS, Alexander BM, Elvin J, Ramkissoon SH. Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors. Front Neurol. 2020;11:544680.

Published In

Front Neurol

DOI

ISSN

1664-2295

Publication Date

2020

Volume

11

Start / End Page

544680

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1109 Neurosciences
  • 1103 Clinical Sciences