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Functional genetic variants of CTNNBIP1 predict platinum treatment response of Chinese epithelial ovarian cancer patients.

Publication ,  Journal Article
Li, H; Chen, L; Tong, X; Dai, H; Shi, T; Cheng, X; Sun, M; Chen, K; Wei, Q; Wang, M
Published in: J Cancer
2020

Chemotherapy resistance remains a blockade for successful treatment and longer overall survival of patients with epithelial ovarian cancer (EOC). CTNNBIP1 is an inhibitor of β-catenin that is a chemotherapeutic target for EOC treatment. In the present study, we investigated associations between single nucleotide polymorphisms (SNPs) of CTNNBIP1 and platinum treatment response of Han Chinese EOC patients and subsequently performed functional prediction and validation of the resultant SNPs. We found that CTNNBIP1 rs935072 AT/TT variant genotypes were associated with platinum treatment response in the multivariate logistic regression analysis of EOC patients. Specifically, the CTNNBIP1 rs935072 AT/TT genotypes were associated with a decreased risk of developing chemoresistance ([adjusted odds ratio (OR)] = 0.89, 95% confidence interval (CI) = 0.82-0.97 and P=0.010), compared with the AA genotype. Further experiments showed that the underlying mechanism for the CTNNBIP1 rs935072 A>T change in chemotherapy treatment response resulted from a lower binding affinity of miR-27a-3p, thereby leading to up-regulation of the CTNNBIP1 expression. We further found that overexpression of CTNNBIP1 sensitized ovarian cancer cells to platinum treatment. Thus, the present study provides evidence that functional variants of CTNNBIP1 may regulate the expression of CTNNBIP1, a possible mechanism affecting platinum treatment response of EOC patients.

Duke Scholars

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Published In

J Cancer

DOI

ISSN

1837-9664

Publication Date

2020

Volume

11

Issue

23

Start / End Page

6850 / 6860

Location

Australia

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Li, H., Chen, L., Tong, X., Dai, H., Shi, T., Cheng, X., … Wang, M. (2020). Functional genetic variants of CTNNBIP1 predict platinum treatment response of Chinese epithelial ovarian cancer patients. J Cancer, 11(23), 6850–6860. https://doi.org/10.7150/jca.48218
Li, Haoran, Lihua Chen, Xiaoxia Tong, Hongji Dai, Tingyan Shi, Xi Cheng, Menghong Sun, Kexin Chen, Qingyi Wei, and Mengyun Wang. “Functional genetic variants of CTNNBIP1 predict platinum treatment response of Chinese epithelial ovarian cancer patients.J Cancer 11, no. 23 (2020): 6850–60. https://doi.org/10.7150/jca.48218.
Li H, Chen L, Tong X, Dai H, Shi T, Cheng X, et al. Functional genetic variants of CTNNBIP1 predict platinum treatment response of Chinese epithelial ovarian cancer patients. J Cancer. 2020;11(23):6850–60.
Li, Haoran, et al. “Functional genetic variants of CTNNBIP1 predict platinum treatment response of Chinese epithelial ovarian cancer patients.J Cancer, vol. 11, no. 23, 2020, pp. 6850–60. Pubmed, doi:10.7150/jca.48218.
Li H, Chen L, Tong X, Dai H, Shi T, Cheng X, Sun M, Chen K, Wei Q, Wang M. Functional genetic variants of CTNNBIP1 predict platinum treatment response of Chinese epithelial ovarian cancer patients. J Cancer. 2020;11(23):6850–6860.

Published In

J Cancer

DOI

ISSN

1837-9664

Publication Date

2020

Volume

11

Issue

23

Start / End Page

6850 / 6860

Location

Australia

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis