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Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease.

Publication ,  Journal Article
Pang, Z; Zhang, L; Coaker, G; Ma, W; He, S-Y; Wang, N
Published in: Plant physiology
October 2020

Citrus Huanglongbing (HLB), caused by Candidatus Liberibacter asiaticus (Las), is one of the most destructive citrus diseases worldwide, yet how Las causes HLB is poorly understood. Here we show that a Las-secreted protein, SDE15 (CLIBASIA_04025), suppresses plant immunity and promotes Las multiplication. Transgenic expression of SDE15 in Duncan grapefruit (Citrus × paradisi) suppresses the hypersensitive response induced by Xanthomonas citri ssp. citri (Xcc) and reduces the expression of immunity-related genes. SDE15 also suppresses the hypersensitive response triggered by the Xanthomonas vesicatoria effector protein AvrBsT in Nicotiana benthamiana, suggesting that it may be a broad-spectrum suppressor of plant immunity. SDE15 interacts with the citrus protein CsACD2, a homolog of Arabidopsis (Arabidopsis thaliana) ACCELERATED CELL DEATH 2 (ACD2). SDE15 suppression of plant immunity is dependent on CsACD2, and overexpression of CsACD2 in citrus suppresses plant immunity and promotes Las multiplication, phenocopying overexpression of SDE15. Identification of CsACD2 as a susceptibility target has implications in genome editing for novel plant resistance against devastating HLB.

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Published In

Plant physiology

DOI

EISSN

1532-2548

ISSN

0032-0889

Publication Date

October 2020

Volume

184

Issue

2

Start / End Page

792 / 805

Related Subject Headings

  • Plants, Genetically Modified
  • Plant Immunity
  • Plant Biology & Botany
  • Oxidoreductases
  • Liberibacter
  • Host-Pathogen Interactions
  • Citrus sinensis
  • Bacterial Proteins
  • Arabidopsis Proteins
  • Apoptosis Regulatory Proteins
 

Citation

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Pang, Z., Zhang, L., Coaker, G., Ma, W., He, S.-Y., & Wang, N. (2020). Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease. Plant Physiology, 184(2), 792–805. https://doi.org/10.1104/pp.20.00348
Pang, Zhiqian, Li Zhang, Gitta Coaker, Wenbo Ma, Sheng-Yang He, and Nian Wang. “Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease.Plant Physiology 184, no. 2 (October 2020): 792–805. https://doi.org/10.1104/pp.20.00348.
Pang Z, Zhang L, Coaker G, Ma W, He S-Y, Wang N. Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease. Plant physiology. 2020 Oct;184(2):792–805.
Pang, Zhiqian, et al. “Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease.Plant Physiology, vol. 184, no. 2, Oct. 2020, pp. 792–805. Epmc, doi:10.1104/pp.20.00348.
Pang Z, Zhang L, Coaker G, Ma W, He S-Y, Wang N. Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease. Plant physiology. 2020 Oct;184(2):792–805.

Published In

Plant physiology

DOI

EISSN

1532-2548

ISSN

0032-0889

Publication Date

October 2020

Volume

184

Issue

2

Start / End Page

792 / 805

Related Subject Headings

  • Plants, Genetically Modified
  • Plant Immunity
  • Plant Biology & Botany
  • Oxidoreductases
  • Liberibacter
  • Host-Pathogen Interactions
  • Citrus sinensis
  • Bacterial Proteins
  • Arabidopsis Proteins
  • Apoptosis Regulatory Proteins