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Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium.

Publication ,  Journal Article
Abraham, WT; Psotka, MA; Fiuzat, M; Filippatos, G; Lindenfeld, J; Mehran, R; Ambardekar, AV; Carson, PE; Jacob, R; Januzzi, JL; Konstam, MA ...
Published in: JACC Heart Fail
December 2020

The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of leading heart failure (HF) academic research investigators, patients, United States (US) Food and Drug Administration representatives, and industry members from the US and Europe. A series of meetings were convened to establish definitions and key concepts for the evaluation of HF therapies including optimal medical and device background therapy, clinical trial design elements and statistical concepts, and study endpoints. This manuscript summarizes the expert panel discussions as consensus recommendations focused on populations and endpoint definitions; it is not exhaustive or restrictive, but designed to stimulate HF clinical trial innovation.

Duke Scholars

Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

December 2020

Volume

8

Issue

12

Start / End Page

961 / 972

Location

United States

Related Subject Headings

  • United States
  • Humans
  • Heart Valve Prosthesis Implantation
  • Heart Failure
  • Endpoint Determination
  • Consensus
  • Cardiac Catheterization
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Abraham, W. T., Psotka, M. A., Fiuzat, M., Filippatos, G., Lindenfeld, J., Mehran, R., … O’Connor, C. M. (2020). Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium. JACC Heart Fail, 8(12), 961–972. https://doi.org/10.1016/j.jchf.2020.10.002
Abraham, William T., Mitchell A. Psotka, Mona Fiuzat, Gerasimos Filippatos, JoAnn Lindenfeld, Roxana Mehran, Amrut V. Ambardekar, et al. “Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium.JACC Heart Fail 8, no. 12 (December 2020): 961–72. https://doi.org/10.1016/j.jchf.2020.10.002.
Abraham WT, Psotka MA, Fiuzat M, Filippatos G, Lindenfeld J, Mehran R, et al. Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium. JACC Heart Fail. 2020 Dec;8(12):961–72.
Abraham, William T., et al. “Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium.JACC Heart Fail, vol. 8, no. 12, Dec. 2020, pp. 961–72. Pubmed, doi:10.1016/j.jchf.2020.10.002.
Abraham WT, Psotka MA, Fiuzat M, Filippatos G, Lindenfeld J, Mehran R, Ambardekar AV, Carson PE, Jacob R, Januzzi JL, Konstam MA, Krucoff MW, Lewis EF, Piccini JP, Solomon SD, Stockbridge N, Teerlink JR, Unger EF, Zeitler EP, Anker SD, O’Connor CM. Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium. JACC Heart Fail. 2020 Dec;8(12):961–972.
Journal cover image

Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

December 2020

Volume

8

Issue

12

Start / End Page

961 / 972

Location

United States

Related Subject Headings

  • United States
  • Humans
  • Heart Valve Prosthesis Implantation
  • Heart Failure
  • Endpoint Determination
  • Consensus
  • Cardiac Catheterization
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology