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Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.

Publication ,  Journal Article
Peres, LC; Bethea, TN; Camacho, TF; Bandera, EV; Beeghly-Fadiel, A; Chyn, DL; Harris, HR; Joslin, CE; Moorman, PG; Myers, E; Ochs-Balcom, HM ...
Published in: J Natl Cancer Inst
June 1, 2021

BACKGROUND: The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women. METHODS: We used data from 4 case-control studies and 3 case-control studies nested within prospective cohorts in the Ovarian Cancer in Women of African Ancestry Consortium to estimate race-specific associations of 10 known or suspected EOC risk factors using logistic regression. Using the Bruzzi method, race-specific population attributable risks (PAR) were estimated for each risk factor individually and collectively, including groupings of exposures (reproductive factors and modifiable factors). All statistical tests were 2-sided. RESULTS: Among 3244 White EOC cases and 9638 controls and 1052 AA EOC cases and 2410 controls, AA women had a statistically significantly higher PAR (false discovery rate [FDR] P < .001) for first-degree family history of breast cancer (PAR = 10.1%, 95% confidence interval [CI] = 6.5% to 13.7%) compared with White women (PAR = 2.6%, 95% CI = 0.8% to 4.4%). After multiple test correction, AA women had a higher PAR than White women when evaluating all risk factors collectively (PAR = 61.6%, 95% CI = 48.6% to 71.3% vs PAR = 43.0%, 95% CI = 32.8% to 51.4%, respectively; FDR P = .06) and for modifiable exposures, including body mass index, oral contraceptives, aspirin, and body powder (PAR = 36.0%, 95% CI = 21.0% to 48.8% vs PAR = 13.8%, 95% CI = 4.5% to 21.8%, respectively; FDR P = .04). CONCLUSIONS: Collectively, the selected risk factors accounted for slightly more of the risk among AA than White women, and interventions to reduce EOC incidence that are focused on multiple modifiable risk factors may be slightly more beneficial to AA women than White women at risk for EOC.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

June 1, 2021

Volume

113

Issue

6

Start / End Page

710 / 718

Location

United States

Related Subject Headings

  • Risk Factors
  • Race Factors
  • Prospective Studies
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Case-Control Studies
  • Carcinoma, Ovarian Epithelial
  • Black or African American
 

Citation

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Peres, L. C., Bethea, T. N., Camacho, T. F., Bandera, E. V., Beeghly-Fadiel, A., Chyn, D. L., … Schildkraut, J. M. (2021). Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium. J Natl Cancer Inst, 113(6), 710–718. https://doi.org/10.1093/jnci/djaa188
Peres, Lauren C., Traci N. Bethea, Tareq F. Camacho, Elisa V. Bandera, Alicia Beeghly-Fadiel, Deanna L. Chyn, Holly R. Harris, et al. “Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.J Natl Cancer Inst 113, no. 6 (June 1, 2021): 710–18. https://doi.org/10.1093/jnci/djaa188.
Peres LC, Bethea TN, Camacho TF, Bandera EV, Beeghly-Fadiel A, Chyn DL, et al. Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium. J Natl Cancer Inst. 2021 Jun 1;113(6):710–8.
Peres, Lauren C., et al. “Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium.J Natl Cancer Inst, vol. 113, no. 6, June 2021, pp. 710–18. Pubmed, doi:10.1093/jnci/djaa188.
Peres LC, Bethea TN, Camacho TF, Bandera EV, Beeghly-Fadiel A, Chyn DL, Harris HR, Joslin CE, Moorman PG, Myers E, Ochs-Balcom HM, Rosenow W, Setiawan VW, Wu AH, Rosenberg L, Schildkraut JM. Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium. J Natl Cancer Inst. 2021 Jun 1;113(6):710–718.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

June 1, 2021

Volume

113

Issue

6

Start / End Page

710 / 718

Location

United States

Related Subject Headings

  • Risk Factors
  • Race Factors
  • Prospective Studies
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Case-Control Studies
  • Carcinoma, Ovarian Epithelial
  • Black or African American