Abstract P481: Early Recognition of Heart Failure With Preserved Ejection Fraction (HFpEF): Ventricular Elastance as a Predictive Marker for Prevention and Treatment
Lekavich, CL; Kraus, WE
Published in: Circulation
Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, carries a 50% mortality rate within 3 years of diagnosis with evidence to support early lifestyle behavioral modification as beneficial. Developing an understanding of markers that identify patients early, promotes early recognition and treatment.
Use of a predictive marker, ventricular elastance, enables early identification of patients at-risk for HFpEF.
Patients previously diagnosed with HFpEF were retrospectively identified. Through case-control and hierarchical linear regression modeling, biomarkers were identified that preceded the onset of HFpEF. Using Cox regression, we conducted a survival analysis to determine time to onset of HFpEF for each biomarker. Using repeated measures logistic regression, continuous variables were tested for interval progression toward disease onset, controlling for co-variates: age, race and sex.
Through retrospective analysis, 251 patients and 775 echocardiograms spanning nearly 20 years were identified. Through mixed linear regression, for the entire model, 7 biomarkers were identified as statistically significant and 1 biomarker, ventricular elastance (Ees), progressively increased leading to the time of HFpEF hospitalization.
This study provides the methodology for testing a predictive marker, ventricular elastance, that enables early recognition of HFpEF.