Skip to main content

Abstract P481: Early Recognition of Heart Failure With Preserved Ejection Fraction (HFpEF): Ventricular Elastance as a Predictive Marker for Prevention and Treatment

Publication ,  Conference
Lekavich, CL; Kraus, WE
Published in: Circulation
March 3, 2020

Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, carries a 50% mortality rate within 3 years of diagnosis with evidence to support early lifestyle behavioral modification as beneficial. Developing an understanding of markers that identify patients early, promotes early recognition and treatment. Use of a predictive marker, ventricular elastance, enables early identification of patients at-risk for HFpEF. Patients previously diagnosed with HFpEF were retrospectively identified. Through case-control and hierarchical linear regression modeling, biomarkers were identified that preceded the onset of HFpEF. Using Cox regression, we conducted a survival analysis to determine time to onset of HFpEF for each biomarker. Using repeated measures logistic regression, continuous variables were tested for interval progression toward disease onset, controlling for co-variates: age, race and sex. Through retrospective analysis, 251 patients and 775 echocardiograms spanning nearly 20 years were identified. Through mixed linear regression, for the entire model, 7 biomarkers were identified as statistically significant and 1 biomarker, ventricular elastance (Ees), progressively increased leading to the time of HFpEF hospitalization. This study provides the methodology for testing a predictive marker, ventricular elastance, that enables early recognition of HFpEF.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

ISSN

0009-7322

Publication Date

March 3, 2020

Volume

141

Issue

Suppl_1

Publisher

Ovid Technologies (Wolters Kluwer Health)

Related Subject Headings

  • Cardiovascular System & Hematology
  • 4207 Sports science and exercise
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lekavich, C. L., & Kraus, W. E. (2020). Abstract P481: Early Recognition of Heart Failure With Preserved Ejection Fraction (HFpEF): Ventricular Elastance as a Predictive Marker for Prevention and Treatment. In Circulation (Vol. 141). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1161/circ.141.suppl_1.p481
Lekavich, Carolyn L., and William E. Kraus. “Abstract P481: Early Recognition of Heart Failure With Preserved Ejection Fraction (HFpEF): Ventricular Elastance as a Predictive Marker for Prevention and Treatment.” In Circulation, Vol. 141. Ovid Technologies (Wolters Kluwer Health), 2020. https://doi.org/10.1161/circ.141.suppl_1.p481.
Lekavich, Carolyn L., and William E. Kraus. “Abstract P481: Early Recognition of Heart Failure With Preserved Ejection Fraction (HFpEF): Ventricular Elastance as a Predictive Marker for Prevention and Treatment.” Circulation, vol. 141, no. Suppl_1, Ovid Technologies (Wolters Kluwer Health), 2020. Crossref, doi:10.1161/circ.141.suppl_1.p481.

Published In

Circulation

DOI

EISSN

1524-4539

ISSN

0009-7322

Publication Date

March 3, 2020

Volume

141

Issue

Suppl_1

Publisher

Ovid Technologies (Wolters Kluwer Health)

Related Subject Headings

  • Cardiovascular System & Hematology
  • 4207 Sports science and exercise
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology