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A Novel Virus Alters Gene Expression and Vacuolar Morphology in Malassezia Cells and Induces a TLR3-Mediated Inflammatory Immune Response

Publication ,  Journal Article
Park, M; Cho, Y-J; Kim, D; Yang, C-S; Lee, SM; Dawson, TL; Nakamizo, S; Kabashima, K; Lee, YW; Jung, WH
Published in: mBio
October 27, 2020

is the most dominant fungal genus on the human skin surface and is associated with various skin diseases including dandruff and seborrheic dermatitis. Among species, is the most widely observed species on the human skin. In the current study, we identified a novel dsRNA virus, named MrV40, in and characterized the sequence and structure of the viral genome along with an independent satellite dsRNA viral segment. Moreover, expression of genes involved in ribosomal synthesis and programmed cell death was altered, indicating that virus infection affected the physiology of the fungal host cells. Our data also showed that the viral nucleic acid from MrV40 induces a TLR3-mediated inflammatory immune response in bone marrow-derived dendritic cells, indicating that a viral element likely contributes to the pathogenicity of . This is the first study to identify and characterize a novel mycovirus in .

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Published In

mBio

DOI

EISSN

2150-7511

ISSN

2161-2129

Publication Date

October 27, 2020

Volume

11

Issue

5

Publisher

American Society for Microbiology

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 0605 Microbiology
 

Citation

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Park, M., Cho, Y.-J., Kim, D., Yang, C.-S., Lee, S. M., Dawson, T. L., … Jung, W. H. (2020). A Novel Virus Alters Gene Expression and Vacuolar Morphology in Malassezia Cells and Induces a TLR3-Mediated Inflammatory Immune Response. MBio, 11(5). https://doi.org/10.1128/mbio.01521-20
Park, Minji, Yong-Joon Cho, Donggyu Kim, Chul-Su Yang, Shi Mun Lee, Thomas L. Dawson, Satoshi Nakamizo, Kenji Kabashima, Yang Won Lee, and Won Hee Jung. “A Novel Virus Alters Gene Expression and Vacuolar Morphology in Malassezia Cells and Induces a TLR3-Mediated Inflammatory Immune Response.” Edited by Floyd L. Wormley. MBio 11, no. 5 (October 27, 2020). https://doi.org/10.1128/mbio.01521-20.
Park M, Cho Y-J, Kim D, Yang C-S, Lee SM, Dawson TL, et al. A Novel Virus Alters Gene Expression and Vacuolar Morphology in Malassezia Cells and Induces a TLR3-Mediated Inflammatory Immune Response. Wormley FL, editor. mBio. 2020 Oct 27;11(5).
Park, Minji, et al. “A Novel Virus Alters Gene Expression and Vacuolar Morphology in Malassezia Cells and Induces a TLR3-Mediated Inflammatory Immune Response.” MBio, edited by Floyd L. Wormley, vol. 11, no. 5, American Society for Microbiology, Oct. 2020. Crossref, doi:10.1128/mbio.01521-20.
Park M, Cho Y-J, Kim D, Yang C-S, Lee SM, Dawson TL, Nakamizo S, Kabashima K, Lee YW, Jung WH. A Novel Virus Alters Gene Expression and Vacuolar Morphology in Malassezia Cells and Induces a TLR3-Mediated Inflammatory Immune Response. Wormley FL, editor. mBio. American Society for Microbiology; 2020 Oct 27;11(5).

Published In

mBio

DOI

EISSN

2150-7511

ISSN

2161-2129

Publication Date

October 27, 2020

Volume

11

Issue

5

Publisher

American Society for Microbiology

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 0605 Microbiology