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Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus.

Publication ,  Journal Article
van Zuydam, NR; Ladenvall, C; Voight, BF; Strawbridge, RJ; Fernandez-Tajes, J; Rayner, NW; Robertson, NR; Mahajan, A; Vlachopoulou, E; Goel, A ...
Published in: Circ Genom Precis Med
December 2020

BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.

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Published In

Circ Genom Precis Med

DOI

EISSN

2574-8300

Publication Date

December 2020

Volume

13

Issue

6

Start / End Page

e002769

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Genetic
  • Meta-Analysis as Topic
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Diabetes Mellitus, Type 2
  • Coronary Artery Disease
  • Case-Control Studies
 

Citation

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van Zuydam, N. R., Ladenvall, C., Voight, B. F., Strawbridge, R. J., Fernandez-Tajes, J., Rayner, N. W., … SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee*, . (2020). Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus. Circ Genom Precis Med, 13(6), e002769. https://doi.org/10.1161/CIRCGEN.119.002769
Zuydam, Natalie R. van, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N William Rayner, Neil R. Robertson, et al. “Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus.Circ Genom Precis Med 13, no. 6 (December 2020): e002769. https://doi.org/10.1161/CIRCGEN.119.002769.
van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, et al. Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus. Circ Genom Precis Med. 2020 Dec;13(6):e002769.
van Zuydam, Natalie R., et al. “Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus.Circ Genom Precis Med, vol. 13, no. 6, Dec. 2020, p. e002769. Pubmed, doi:10.1161/CIRCGEN.119.002769.
van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, Robertson NR, Mahajan A, Vlachopoulou E, Goel A, Kleber ME, Nelson CP, Kwee LC, Esko T, Mihailov E, Mägi R, Milani L, Fischer K, Kanoni S, Kumar J, Song C, Hartiala JA, Pedersen NL, Perola M, Gieger C, Peters A, Qu L, Willems SM, Doney ASF, Morris AD, Zheng Y, Sesti G, Hu FB, Qi L, Laakso M, Thorsteinsdottir U, Grallert H, van Duijn C, Reilly MP, Ingelsson E, Deloukas P, Kathiresan S, Metspalu A, Shah SH, Sinisalo J, Salomaa V, Hamsten A, Samani NJ, März W, Hazen SL, Watkins H, Saleheen D, Morris AP, Colhoun HM, Groop L, McCarthy MI, Palmer CNA, SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee*. Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus. Circ Genom Precis Med. 2020 Dec;13(6):e002769.

Published In

Circ Genom Precis Med

DOI

EISSN

2574-8300

Publication Date

December 2020

Volume

13

Issue

6

Start / End Page

e002769

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Genetic
  • Meta-Analysis as Topic
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Diabetes Mellitus, Type 2
  • Coronary Artery Disease
  • Case-Control Studies