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Frailty and aging-associated syndromes in lung transplant candidates and recipients.

Publication ,  Journal Article
Schaenman, JM; Diamond, JM; Greenland, JR; Gries, C; Kennedy, CC; Parulekar, AD; Rozenberg, D; Singer, JP; Singer, LG; Snyder, LD; Bhorade, S
Published in: Am J Transplant
June 2021

Many lung transplant candidates and recipients are older and frailer compared to previous eras. Older patients are at increased risk for pre- and posttransplant mortality, but this risk is not explained by numerical age alone. This manuscript represents the product of the American Society of Transplantation (AST) conference on frailty. Experts in the field reviewed the latest published research on assessment of elderly and frail lung transplant candidates. Physical frailty, often defined as slowness, weakness, low physical activity, shrinking, and exhaustion, and frailty evaluation is an important tool for evaluation of age-associated dysfunction. Another approach is assessment by cumulative deficits, and both types of frailty are common in lung transplant candidates. Frailty is associated with death or delisting before transplant, and may be associated with posttransplant mortality. Sarcopenia, cognitive dysfunction, depression, and nutrition are other important components for patient evaluation. Aging-associated inflammation, telomere dysfunction, and adaptive immune system senescence may also contribute to frailty. Developing tools for frailty assessment and interventions holds promise for improving patient outcomes before and after lung transplantation.

Duke Scholars

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

June 2021

Volume

21

Issue

6

Start / End Page

2018 / 2024

Location

United States

Related Subject Headings

  • Syndrome
  • Surgery
  • Sarcopenia
  • Lung Transplantation
  • Humans
  • Frailty
  • Frail Elderly
  • Aging
  • Aged
  • 3204 Immunology
 

Citation

APA
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MLA
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Schaenman, J. M., Diamond, J. M., Greenland, J. R., Gries, C., Kennedy, C. C., Parulekar, A. D., … Bhorade, S. (2021). Frailty and aging-associated syndromes in lung transplant candidates and recipients. Am J Transplant, 21(6), 2018–2024. https://doi.org/10.1111/ajt.16439
Schaenman, Joanna M., Joshua M. Diamond, John R. Greenland, Cynthia Gries, Cassie C. Kennedy, Amit D. Parulekar, Dmitry Rozenberg, et al. “Frailty and aging-associated syndromes in lung transplant candidates and recipients.Am J Transplant 21, no. 6 (June 2021): 2018–24. https://doi.org/10.1111/ajt.16439.
Schaenman JM, Diamond JM, Greenland JR, Gries C, Kennedy CC, Parulekar AD, et al. Frailty and aging-associated syndromes in lung transplant candidates and recipients. Am J Transplant. 2021 Jun;21(6):2018–24.
Schaenman, Joanna M., et al. “Frailty and aging-associated syndromes in lung transplant candidates and recipients.Am J Transplant, vol. 21, no. 6, June 2021, pp. 2018–24. Pubmed, doi:10.1111/ajt.16439.
Schaenman JM, Diamond JM, Greenland JR, Gries C, Kennedy CC, Parulekar AD, Rozenberg D, Singer JP, Singer LG, Snyder LD, Bhorade S. Frailty and aging-associated syndromes in lung transplant candidates and recipients. Am J Transplant. 2021 Jun;21(6):2018–2024.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

June 2021

Volume

21

Issue

6

Start / End Page

2018 / 2024

Location

United States

Related Subject Headings

  • Syndrome
  • Surgery
  • Sarcopenia
  • Lung Transplantation
  • Humans
  • Frailty
  • Frail Elderly
  • Aging
  • Aged
  • 3204 Immunology