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N6-Methyladenosine Regulates Host Responses to Viral Infection.

Publication ,  Journal Article
McFadden, MJ; Horner, SM
Published in: Trends Biochem Sci
May 2021

Recent discoveries have revealed that, during viral infection, the presence of the RNA modification N6-methyladenosine (m6A) on viral and cellular RNAs has profound impacts on infection outcome. Although m6A directly regulates many viral RNA processes, its effects on cellular RNAs and pathways during infection have only recently begun to be elucidated. Disentangling the effects of m6A on viral and host RNAs remains a challenge for the field. m6A has been found to regulate host responses such as viral RNA sensing, cytokine responses, and immune cell functions. We highlight recent findings describing how m6A modulates host responses to viral infection and discuss future directions that will lead to a synergistic understanding of the processes by which m6A regulates viral infection.

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Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

May 2021

Volume

46

Issue

5

Start / End Page

366 / 377

Location

England

Related Subject Headings

  • Virus Diseases
  • RNA, Viral
  • Immunity, Innate
  • Humans
  • Developmental Biology
  • Cytokines
  • Adenosine
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics
  • 3101 Biochemistry and cell biology
 

Citation

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McFadden, M. J., & Horner, S. M. (2021). N6-Methyladenosine Regulates Host Responses to Viral Infection. Trends Biochem Sci, 46(5), 366–377. https://doi.org/10.1016/j.tibs.2020.11.008
McFadden, Michael J., and Stacy M. Horner. “N6-Methyladenosine Regulates Host Responses to Viral Infection.Trends Biochem Sci 46, no. 5 (May 2021): 366–77. https://doi.org/10.1016/j.tibs.2020.11.008.
McFadden MJ, Horner SM. N6-Methyladenosine Regulates Host Responses to Viral Infection. Trends Biochem Sci. 2021 May;46(5):366–77.
McFadden, Michael J., and Stacy M. Horner. “N6-Methyladenosine Regulates Host Responses to Viral Infection.Trends Biochem Sci, vol. 46, no. 5, May 2021, pp. 366–77. Pubmed, doi:10.1016/j.tibs.2020.11.008.
McFadden MJ, Horner SM. N6-Methyladenosine Regulates Host Responses to Viral Infection. Trends Biochem Sci. 2021 May;46(5):366–377.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

May 2021

Volume

46

Issue

5

Start / End Page

366 / 377

Location

England

Related Subject Headings

  • Virus Diseases
  • RNA, Viral
  • Immunity, Innate
  • Humans
  • Developmental Biology
  • Cytokines
  • Adenosine
  • 3404 Medicinal and biomolecular chemistry
  • 3205 Medical biochemistry and metabolomics
  • 3101 Biochemistry and cell biology