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Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.

Publication ,  Journal Article
Wisdom, AJ; Kirsch, DG
Published in: Cancer Res
December 15, 2020

DNA polymerase mutations can cause hypermutant cancers, but the mechanisms of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly understood. In this issue of Cancer Research, Galati and colleagues investigate the effects of cancer-associated DNA polymerase ϵ (Pole) mutations on tumorigenesis and response to immune checkpoint blockade. They describe novel genetically engineered mouse models harboring cancer-associated Pole mutations and examine the effects of these mutations on tumorigenesis, the tumor mutational landscape, and the tumor immune microenvironment. Integrating this information with an emerging understanding of how different tumor mutations influence the response to immunotherapy may aid in prediction, diagnosis, and treatment of Pole-mutant tumors.See related article by Galati et al., p. 5606.

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Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

December 15, 2020

Volume

80

Issue

24

Start / End Page

5459 / 5461

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Mice
  • Immunotherapy
  • Immune Checkpoint Inhibitors
  • DNA Polymerase II
  • Animals
  • 3211 Oncology and carcinogenesis
 

Citation

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Wisdom, A. J., & Kirsch, D. G. (2020). Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer. Cancer Res, 80(24), 5459–5461. https://doi.org/10.1158/0008-5472.CAN-20-3241
Wisdom, Amy J., and David G. Kirsch. “Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.Cancer Res 80, no. 24 (December 15, 2020): 5459–61. https://doi.org/10.1158/0008-5472.CAN-20-3241.
Wisdom AJ, Kirsch DG. Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer. Cancer Res. 2020 Dec 15;80(24):5459–61.
Wisdom, Amy J., and David G. Kirsch. “Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.Cancer Res, vol. 80, no. 24, Dec. 2020, pp. 5459–61. Pubmed, doi:10.1158/0008-5472.CAN-20-3241.
Wisdom AJ, Kirsch DG. Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer. Cancer Res. 2020 Dec 15;80(24):5459–5461.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

December 15, 2020

Volume

80

Issue

24

Start / End Page

5459 / 5461

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Mice
  • Immunotherapy
  • Immune Checkpoint Inhibitors
  • DNA Polymerase II
  • Animals
  • 3211 Oncology and carcinogenesis