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Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration.

Publication ,  Journal Article
Moiseenko, A; Vazquez-Armendariz, AI; Kheirollahi, V; Chu, X; Tata, A; Rivetti, S; Günther, S; Lebrigand, K; Herold, S; Braun, T; Mari, B ...
Published in: Cell Rep
December 22, 2020

Tissue regeneration requires coordinated and dynamic remodeling of stem and progenitor cells and the surrounding niche. Although the plasticity of epithelial cells has been well explored in many tissues, the dynamic changes occurring in niche cells remain elusive. Here, we show that, during lung repair after naphthalene injury, a population of PDGFRα+ cells emerges in the non-cartilaginous conducting airway niche, which is normally populated by airway smooth muscle cells (ASMCs). This cell population, which we term "repair-supportive mesenchymal cells" (RSMCs), is distinct from conventional ASMCs, which have previously been shown to contribute to epithelial repair. Gene expression analysis on sorted lineage-labeled cells shows that RSMCs express low levels of ASMC markers, but high levels of the pro-regenerative marker Fgf10. Organoid co-cultures demonstrate an enhanced ability for RSMCs in supporting club-cell growth. Our study highlights the dynamics of mesenchymal cells in the airway niche and has implications for chronic airway-injury-associated diseases.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

December 22, 2020

Volume

33

Issue

12

Start / End Page

108549

Location

United States

Related Subject Headings

  • Mice
  • Mesenchymal Stem Cells
  • Humans
  • Guided Tissue Regeneration
  • Female
  • Epithelial Cells
  • Animals
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology
 

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Moiseenko, A., Vazquez-Armendariz, A. I., Kheirollahi, V., Chu, X., Tata, A., Rivetti, S., … El Agha, E. (2020). Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration. Cell Rep, 33(12), 108549. https://doi.org/10.1016/j.celrep.2020.108549
Moiseenko, Alena, Ana Ivonne Vazquez-Armendariz, Vahid Kheirollahi, Xuran Chu, Aleksandra Tata, Stefano Rivetti, Stefan Günther, et al. “Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration.Cell Rep 33, no. 12 (December 22, 2020): 108549. https://doi.org/10.1016/j.celrep.2020.108549.
Moiseenko A, Vazquez-Armendariz AI, Kheirollahi V, Chu X, Tata A, Rivetti S, et al. Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration. Cell Rep. 2020 Dec 22;33(12):108549.
Moiseenko, Alena, et al. “Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration.Cell Rep, vol. 33, no. 12, Dec. 2020, p. 108549. Pubmed, doi:10.1016/j.celrep.2020.108549.
Moiseenko A, Vazquez-Armendariz AI, Kheirollahi V, Chu X, Tata A, Rivetti S, Günther S, Lebrigand K, Herold S, Braun T, Mari B, De Langhe S, Kwapiszewska G, Günther A, Chen C, Seeger W, Tata PR, Zhang J-S, Bellusci S, El Agha E. Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration. Cell Rep. 2020 Dec 22;33(12):108549.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

December 22, 2020

Volume

33

Issue

12

Start / End Page

108549

Location

United States

Related Subject Headings

  • Mice
  • Mesenchymal Stem Cells
  • Humans
  • Guided Tissue Regeneration
  • Female
  • Epithelial Cells
  • Animals
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology