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IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405.

Publication ,  Journal Article
Guercio, BJ; Zhang, S; Ou, F-S; Venook, AP; Niedzwiecki, D; Lenz, H-J; Innocenti, F; Pollak, MN; Nixon, AB; Mullen, BC; O'Neil, BH; Shaw, JE ...
Published in: JNCI Cancer Spectr
February 2021

BACKGROUND: Energy balance-related biomarkers are associated with risk and prognosis of various malignancies. Their relationship to survival in metastatic colorectal cancer (mCRC) requires further study. METHODS: Baseline plasma insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3, IGFBP-7, C-peptide, and adiponectin were measured at time of trial registration in a prospective cohort of patients with mCRC participating in a National Cancer Institute-sponsored trial of first-line systemic therapy. We used Cox proportional hazards regression to adjust for confounders and examine associations of each biomarker with overall survival (OS) and progression-free survival (PFS). P values are 2-sided. RESULTS: Median follow-up for 1086 patients was 6.2 years. Compared with patients in the lowest IGFBP-3 quintile, patients in the highest IGFBP-3 quintile experienced an adjusted hazard ratio (HR) for OS of 0.57 (95% confidence interval [CI] = 0.42 to 0.78; P nonlinearity < .001) and for PFS of 0.61 (95% CI = 0.45 to 0.82; P trend = .003). Compared with patients in the lowest IGFBP-7 quintile, patients in the highest IGFBP-7 quintile experienced an adjusted hazard ratio for OS of 1.60 (95% CI = 1.30 to 1.97; P trend < .001) and for PFS of 1.38 (95% CI = 1.13 to 1.69; P trend < .001). Plasma C-peptide and IGF-1 were not associated with patient outcomes. Adiponectin was not associated with OS; there was a nonlinear U-shaped association between adiponectin and PFS (P nonlinearity = .03). CONCLUSIONS: Among patients with mCRC, high plasma IGFBP-3 and low IGFBP-7 were associated with longer OS and PFS. Extreme levels of adiponectin were associated with shorter PFS. These findings suggest potential avenues for prognostic and therapeutic innovation.

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Published In

JNCI Cancer Spectr

DOI

EISSN

2515-5091

Publication Date

February 2021

Volume

5

Issue

1

Location

England

Related Subject Headings

  • Prospective Studies
  • Proportional Hazards Models
  • Progression-Free Survival
  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor Binding Protein 3
  • Humans
 

Citation

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Chicago
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Guercio, B. J., Zhang, S., Ou, F.-S., Venook, A. P., Niedzwiecki, D., Lenz, H.-J., … Meyerhardt, J. A. (2021). IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405. JNCI Cancer Spectr, 5(1). https://doi.org/10.1093/jncics/pkaa074
Guercio, Brendan J., Sui Zhang, Fang-Shu Ou, Alan P. Venook, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, et al. “IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405.JNCI Cancer Spectr 5, no. 1 (February 2021). https://doi.org/10.1093/jncics/pkaa074.
Guercio BJ, Zhang S, Ou F-S, Venook AP, Niedzwiecki D, Lenz H-J, et al. IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405. JNCI Cancer Spectr. 2021 Feb;5(1).
Guercio, Brendan J., et al. “IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405.JNCI Cancer Spectr, vol. 5, no. 1, Feb. 2021. Pubmed, doi:10.1093/jncics/pkaa074.
Guercio BJ, Zhang S, Ou F-S, Venook AP, Niedzwiecki D, Lenz H-J, Innocenti F, Pollak MN, Nixon AB, Mullen BC, O’Neil BH, Shaw JE, Polite BN, Benson AB, Atkins JN, Goldberg RM, Brown JC, O’Reilly EM, Mayer RJ, Blanke CD, Fuchs CS, Meyerhardt JA. IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405. JNCI Cancer Spectr. 2021 Feb;5(1).

Published In

JNCI Cancer Spectr

DOI

EISSN

2515-5091

Publication Date

February 2021

Volume

5

Issue

1

Location

England

Related Subject Headings

  • Prospective Studies
  • Proportional Hazards Models
  • Progression-Free Survival
  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor Binding Protein 3
  • Humans