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Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.

Publication ,  Journal Article
Silva de Castro, I; Gorini, G; Mason, R; Gorman, J; Bissa, M; Rahman, MA; Arakelyan, A; Kalisz, I; Whitney, S; Becerra-Flores, M; Ni, E ...
Published in: iScience
February 19, 2021
Published version (DOI) Link to item

The efficacy of ALVAC-based HIV and SIV vaccines in humans and macaques correlates with antibodies to envelope variable region 2 (V2). We show here that vaccine-induced antibodies to SIV variable region 1 (V1) inhibit anti-V2 antibody-mediated cytotoxicity and reverse their ability to block V2 peptide interaction with the α4β7 integrin. SIV vaccines engineered to delete V1 and favor an α helix, rather than a β sheet V2 conformation, induced V2-specific ADCC correlating with decreased risk of SIV acquisition. Removal of V1 from the HIV-1 clade A/E A244 envelope resulted in decreased binding to antibodies recognizing V2 in the β sheet conformation. Thus, deletion of V1 in HIV envelope immunogens may improve antibody responses to V2 virus vulnerability sites and increase the efficacy of HIV vaccine candidates.

Duke Scholars

Marina Tuyishime
Author Marina Tuyishime Surgery, Surgical Sciences
Celia Crane LaBranche
Author Celia Crane LaBranche Surgery, Surgical Sciences
David Charles Montefiori
Author David Charles Montefiori Surgery, Surgical Sciences
Georgia Doris Tomaras
Author Georgia Doris Tomaras Surgery, Surgical Sciences
Xiaoying Shen
Author Xiaoying Shen Surgery, Surgical Sciences
Guido Ferrari
Author Guido Ferrari Surgery, Surgical Sciences
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Published In

iScience

DOI

10.1016/j.isci.2021.102047

EISSN

2589-0042

Publication Date

February 19, 2021

Volume

24

Issue

2

Start / End Page

102047

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Silva de Castro, I., Gorini, G., Mason, R., Gorman, J., Bissa, M., Rahman, M. A., … Franchini, G. (2021). Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates. IScience, 24(2), 102047. https://doi.org/10.1016/j.isci.2021.102047
Silva de Castro, Isabela, Giacomo Gorini, Rosemarie Mason, Jason Gorman, Massimiliano Bissa, Mohammad A. Rahman, Anush Arakelyan, et al. “Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.” IScience 24, no. 2 (February 19, 2021): 102047. https://doi.org/10.1016/j.isci.2021.102047.
Silva de Castro I, Gorini G, Mason R, Gorman J, Bissa M, Rahman MA, et al. Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates. iScience. 2021 Feb 19;24(2):102047.
Silva de Castro, Isabela, et al. “Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.” IScience, vol. 24, no. 2, Feb. 2021, p. 102047. Pubmed, doi:10.1016/j.isci.2021.102047.
Silva de Castro I, Gorini G, Mason R, Gorman J, Bissa M, Rahman MA, Arakelyan A, Kalisz I, Whitney S, Becerra-Flores M, Ni E, Peachman K, Trinh HV, Read M, Liu M-H, Van Ryk D, Paquin-Proulx D, Shubin Z, Tuyishime M, Peele J, Ahmadi MS, Verardi R, Hill J, Beddall M, Nguyen R, Stamos JD, Fujikawa D, Min S, Schifanella L, Vaccari M, Galli V, Doster MN, Liyanage NPM, Sarkis S, Caccuri F, LaBranche C, Montefiori DC, Tomaras GD, Shen X, Rosati M, Felber BK, Pavlakis GN, Venzon DJ, Magnanelli W, Breed M, Kramer J, Keele BF, Eller MA, Cicala C, Arthos J, Ferrari G, Margolis L, Robert-Guroff M, Kwong PD, Roederer M, Rao M, Cardozo TJ, Franchini G. Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates. iScience. 2021 Feb 19;24(2):102047.
Journal cover image

Published In

iScience

DOI

10.1016/j.isci.2021.102047

EISSN

2589-0042

Publication Date

February 19, 2021

Volume

24

Issue

2

Start / End Page

102047

Location

United States