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Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer.

Publication ,  Journal Article
Vyas, R; Aloui, T; Horvath, K; Herr, PJ; Kirley, MP; Parker, CB; Keil, AD; Carlson, JB; Keogh, J; Sperline, RP; Denton, MB; Sartorelli, ML ...
Published in: Journal of the American Society for Mass Spectrometry
February 2021

Cycloidal sector mass analyzers have, in principle, perfect focusing due to perpendicularly oriented uniform electric and magnetic fields, making them ideal candidates for incorporation of spatially coded apertures. We have previously demonstrated a proof-of-concept cycloidal-coded aperture miniature mass spectrometer (C-CAMMS) instrument and achieved a greater than 10-fold increase in throughput without sacrificing resolution, compared with a single slit instrument. However, artifacts were observed in the reconstructed mass spectrum due to nonuniformity in the electric field and misalignment of the detector and the ion source with the mass analyzer focal plane. In this work, we modified the mass analyzer design of the previous C-CAMMS instrument to improve electric field uniformity, improve the alignment of the ion source and the mass analyzer with the detector, and increase the depth-of-focus to further facilitate alignment. A comparison of reconstructed spectra of a mixture of dry air and toluene at different electric fields was performed using the improved C-CAMMS prototype. A reduction in reconstruction artifacts compared to our proof-of-concept C-CAMMS instrument highlights the improved performance enabled by the design changes.

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Published In

Journal of the American Society for Mass Spectrometry

DOI

EISSN

1879-1123

ISSN

1044-0305

Publication Date

February 2021

Volume

32

Issue

2

Start / End Page

509 / 518

Related Subject Headings

  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry
  • 0301 Analytical Chemistry
 

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Vyas, R., Aloui, T., Horvath, K., Herr, P. J., Kirley, M. P., Parker, C. B., … Amsden, J. J. (2021). Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer. Journal of the American Society for Mass Spectrometry, 32(2), 509–518. https://doi.org/10.1021/jasms.0c00378
Vyas, Raul, Tanouir Aloui, Kathleen Horvath, Philip J. Herr, Matthew P. Kirley, Charles B. Parker, Adam D. Keil, et al. “Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer.Journal of the American Society for Mass Spectrometry 32, no. 2 (February 2021): 509–18. https://doi.org/10.1021/jasms.0c00378.
Vyas R, Aloui T, Horvath K, Herr PJ, Kirley MP, Parker CB, et al. Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer. Journal of the American Society for Mass Spectrometry. 2021 Feb;32(2):509–18.
Vyas, Raul, et al. “Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer.Journal of the American Society for Mass Spectrometry, vol. 32, no. 2, Feb. 2021, pp. 509–18. Epmc, doi:10.1021/jasms.0c00378.
Vyas R, Aloui T, Horvath K, Herr PJ, Kirley MP, Parker CB, Keil AD, Carlson JB, Keogh J, Sperline RP, Denton MB, Sartorelli ML, Stoner BR, Gehm ME, Glass JT, Amsden JJ. Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer. Journal of the American Society for Mass Spectrometry. 2021 Feb;32(2):509–518.
Journal cover image

Published In

Journal of the American Society for Mass Spectrometry

DOI

EISSN

1879-1123

ISSN

1044-0305

Publication Date

February 2021

Volume

32

Issue

2

Start / End Page

509 / 518

Related Subject Headings

  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry
  • 0301 Analytical Chemistry