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A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.

Publication ,  Journal Article
Ong, J-S; Dixon-Suen, SC; Han, X; An, J; Esophageal Cancer Consortium, ; 23 and Me Research Team, ; Liyanage, U; Dusingize, J-C; Schumacher, J ...
Published in: Nat Commun
January 11, 2021

Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

January 11, 2021

Volume

12

Issue

1

Start / End Page

246

Location

England

Related Subject Headings

  • Vitamin D
  • Sunburn
  • Risk Factors
  • Pigmentation
  • Neoplasms
  • Multivariate Analysis
  • Mendelian Randomization Analysis
  • Humans
  • Genetic Predisposition to Disease
  • Child
 

Citation

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Ong, J.-S., Dixon-Suen, S. C., Han, X., An, J., Esophageal Cancer Consortium, ., 23 and Me Research Team, ., … MacGregor, S. (2021). A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. Nat Commun, 12(1), 246. https://doi.org/10.1038/s41467-020-20368-w
Ong, Jue-Sheng, Suzanne C. Dixon-Suen, Xikun Han, Jiyuan An, Jiyuan Esophageal Cancer Consortium, Jiyuan 23 and Me Research Team, Upekha Liyanage, et al. “A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.Nat Commun 12, no. 1 (January 11, 2021): 246. https://doi.org/10.1038/s41467-020-20368-w.
Ong J-S, Dixon-Suen SC, Han X, An J, Esophageal Cancer Consortium, 23 and Me Research Team, et al. A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. Nat Commun. 2021 Jan 11;12(1):246.
Ong, Jue-Sheng, et al. “A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.Nat Commun, vol. 12, no. 1, Jan. 2021, p. 246. Pubmed, doi:10.1038/s41467-020-20368-w.
Ong J-S, Dixon-Suen SC, Han X, An J, Esophageal Cancer Consortium, 23 and Me Research Team, Liyanage U, Dusingize J-C, Schumacher J, Gockel I, Böhmer A, Jankowski J, Palles C, O’Mara T, Spurdle A, Law MH, Iles MM, Pharoah P, Berchuck A, Zheng W, Thrift AP, Olsen C, Neale RE, Gharahkhani P, Webb PM, MacGregor S. A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. Nat Commun. 2021 Jan 11;12(1):246.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

January 11, 2021

Volume

12

Issue

1

Start / End Page

246

Location

England

Related Subject Headings

  • Vitamin D
  • Sunburn
  • Risk Factors
  • Pigmentation
  • Neoplasms
  • Multivariate Analysis
  • Mendelian Randomization Analysis
  • Humans
  • Genetic Predisposition to Disease
  • Child