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Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome.

Publication ,  Journal Article
Tang, J; Shen, D; Caranasos, TG; Wang, Z; Vandergriff, AC; Allen, TA; Hensley, MT; Dinh, P-U; Cores, J; Li, T-S; Zhang, J; Kan, Q; Cheng, K
Published in: Nat Commun
January 3, 2017

Stem cell therapy represents a promising strategy in regenerative medicine. However, cells need to be carefully preserved and processed before usage. In addition, cell transplantation carries immunogenicity and/or tumourigenicity risks. Mounting lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion (of regenerative factors) and membrane-based cell-cell interaction with the injured cells. Here, we fabricate a synthetic cell-mimicking microparticle (CMMP) that recapitulates stem cell functions in tissue repair. CMMPs carry similar secreted proteins and membranes as genuine cardiac stem cells do. In a mouse model of myocardial infarction, injection of CMMPs leads to the preservation of viable myocardium and augmentation of cardiac functions similar to cardiac stem cell therapy. CMMPs (derived from human cells) do not stimulate T-cell infiltration in immuno-competent mice. In conclusion, CMMPs act as 'synthetic stem cells' which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration.

Duke Scholars

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

January 3, 2017

Volume

8

Start / End Page

13724

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Stem Cells
  • Recovery of Function
  • Paracrine Communication
  • Myocardium
  • Myocardial Infarction
  • Mice
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Insulin-Like Growth Factor I
 

Citation

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Tang, J., Shen, D., Caranasos, T. G., Wang, Z., Vandergriff, A. C., Allen, T. A., … Cheng, K. (2017). Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nat Commun, 8, 13724. https://doi.org/10.1038/ncomms13724
Tang, Junnan, Deliang Shen, Thomas George Caranasos, Zegen Wang, Adam C. Vandergriff, Tyler A. Allen, Michael Taylor Hensley, et al. “Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome.Nat Commun 8 (January 3, 2017): 13724. https://doi.org/10.1038/ncomms13724.
Tang J, Shen D, Caranasos TG, Wang Z, Vandergriff AC, Allen TA, et al. Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nat Commun. 2017 Jan 3;8:13724.
Tang, Junnan, et al. “Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome.Nat Commun, vol. 8, Jan. 2017, p. 13724. Pubmed, doi:10.1038/ncomms13724.
Tang J, Shen D, Caranasos TG, Wang Z, Vandergriff AC, Allen TA, Hensley MT, Dinh P-U, Cores J, Li T-S, Zhang J, Kan Q, Cheng K. Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nat Commun. 2017 Jan 3;8:13724.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

January 3, 2017

Volume

8

Start / End Page

13724

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Stem Cells
  • Recovery of Function
  • Paracrine Communication
  • Myocardium
  • Myocardial Infarction
  • Mice
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Insulin-Like Growth Factor I