Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome.
Stem cell therapy represents a promising strategy in regenerative medicine. However, cells need to be carefully preserved and processed before usage. In addition, cell transplantation carries immunogenicity and/or tumourigenicity risks. Mounting lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion (of regenerative factors) and membrane-based cell-cell interaction with the injured cells. Here, we fabricate a synthetic cell-mimicking microparticle (CMMP) that recapitulates stem cell functions in tissue repair. CMMPs carry similar secreted proteins and membranes as genuine cardiac stem cells do. In a mouse model of myocardial infarction, injection of CMMPs leads to the preservation of viable myocardium and augmentation of cardiac functions similar to cardiac stem cell therapy. CMMPs (derived from human cells) do not stimulate T-cell infiltration in immuno-competent mice. In conclusion, CMMPs act as 'synthetic stem cells' which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration.
Duke Scholars
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- Vascular Endothelial Growth Factor A
- Stem Cells
- Recovery of Function
- Paracrine Communication
- Myocardium
- Myocardial Infarction
- Mice
- Male
- Intercellular Signaling Peptides and Proteins
- Insulin-Like Growth Factor I
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Vascular Endothelial Growth Factor A
- Stem Cells
- Recovery of Function
- Paracrine Communication
- Myocardium
- Myocardial Infarction
- Mice
- Male
- Intercellular Signaling Peptides and Proteins
- Insulin-Like Growth Factor I