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Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease.

Publication ,  Journal Article
Zhou, J; Tripathi, M; Sinha, RA; Singh, BK; Yen, PM
Published in: Hepatoma Res
2021

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disorder worldwide. It comprises a spectrum of conditions that range from steatosis to non-alcoholic steatohepatitis, with progression to cirrhosis and hepatocellular carcinoma. Currently, there is no FDA-approved pharmacological treatment for NAFLD. The pathogenesis of NAFLD involves genetic and environmental/host factors, including those that cause changes in intestinal microbiota and their metabolites. In this review, we discuss recent findings on the relationship(s) of microbiota signature with severity of NAFLD and the role(s) microbial metabolites in NAFLD progression. We discuss how metabolites may affect NAFLD progression and their potential to serve as biomarkers for NAFLD diagnosis or therapeutic targets for disease management.

Duke Scholars

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Published In

Hepatoma Res

DOI

ISSN

2394-5079

Publication Date

2021

Volume

7

Start / End Page

11

Location

United States
 

Citation

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Chicago
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Zhou, J., Tripathi, M., Sinha, R. A., Singh, B. K., & Yen, P. M. (2021). Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease. Hepatoma Res, 7, 11. https://doi.org/10.20517/2394-5079.2020.134
Zhou, Jin, Madhulika Tripathi, Rohit A. Sinha, Brijesh Kumar Singh, and Paul M. Yen. “Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease.Hepatoma Res 7 (2021): 11. https://doi.org/10.20517/2394-5079.2020.134.
Zhou J, Tripathi M, Sinha RA, Singh BK, Yen PM. Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease. Hepatoma Res. 2021;7:11.
Zhou, Jin, et al. “Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease.Hepatoma Res, vol. 7, 2021, p. 11. Pubmed, doi:10.20517/2394-5079.2020.134.
Zhou J, Tripathi M, Sinha RA, Singh BK, Yen PM. Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease. Hepatoma Res. 2021;7:11.

Published In

Hepatoma Res

DOI

ISSN

2394-5079

Publication Date

2021

Volume

7

Start / End Page

11

Location

United States