State-dependent responses to intracranial brain stimulation in a patient with depression.
Publication
, Journal Article
Scangos, KW; Makhoul, GS; Sugrue, LP; Chang, EF; Krystal, AD
Published in: Nat Med
February 2021
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept for personalized, circuit-specific medicine in psychiatry.
Duke Scholars
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Published In
Nat Med
DOI
EISSN
1546-170X
Publication Date
February 2021
Volume
27
Issue
2
Start / End Page
229 / 231
Location
United States
Related Subject Headings
- Immunology
- Humans
- Female
- Electrodes
- Electric Stimulation
- Depressive Disorder, Major
- Deep Brain Stimulation
- Brain Mapping
- Brain
- Adult
Citation
APA
Chicago
ICMJE
MLA
NLM
Scangos, K. W., Makhoul, G. S., Sugrue, L. P., Chang, E. F., & Krystal, A. D. (2021). State-dependent responses to intracranial brain stimulation in a patient with depression. Nat Med, 27(2), 229–231. https://doi.org/10.1038/s41591-020-01175-8
Scangos, Katherine W., Ghassan S. Makhoul, Leo P. Sugrue, Edward F. Chang, and Andrew D. Krystal. “State-dependent responses to intracranial brain stimulation in a patient with depression.” Nat Med 27, no. 2 (February 2021): 229–31. https://doi.org/10.1038/s41591-020-01175-8.
Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD. State-dependent responses to intracranial brain stimulation in a patient with depression. Nat Med. 2021 Feb;27(2):229–31.
Scangos, Katherine W., et al. “State-dependent responses to intracranial brain stimulation in a patient with depression.” Nat Med, vol. 27, no. 2, Feb. 2021, pp. 229–31. Pubmed, doi:10.1038/s41591-020-01175-8.
Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD. State-dependent responses to intracranial brain stimulation in a patient with depression. Nat Med. 2021 Feb;27(2):229–231.
Published In
Nat Med
DOI
EISSN
1546-170X
Publication Date
February 2021
Volume
27
Issue
2
Start / End Page
229 / 231
Location
United States
Related Subject Headings
- Immunology
- Humans
- Female
- Electrodes
- Electric Stimulation
- Depressive Disorder, Major
- Deep Brain Stimulation
- Brain Mapping
- Brain
- Adult