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Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.

Publication ,  Journal Article
Lin, Y; Bailey, DE; Docherty, SL; Porter, LS; Cooper, BA; Paul, SM; Kober, KM; Hammer, MJ; Wright, F; Dunn, LB; Conley, YP; Levine, JD; Miaskowski, C
Published in: Support Care Cancer
August 2021

PURPOSE: Identify subgroups of gastrointestinal (GI) cancer patients with distinct multiple co-occurring symptom profiles and evaluate for differences among these subgroups in demographic and clinical characteristics and quality of life (QOL) outcomes. METHODS: Patients with GI cancers (n = 399) completed the Memorial Symptom Assessment Scale (MSAS) that was used to assess for multiple co-occurring symptoms. Latent class analysis (LCA) was used to identify subgroups of patients with distinct symptom profiles using symptom occurrence ratings. Differences in demographic and clinical characteristics and QOL outcomes among the subgroups were evaluated using parametric and nonparametric tests. RESULTS: All Low (36.6%), Moderate (49.4%), and All High (14.0%) classes were identified. Compared to the All Low class, patients in the other two classes were significantly younger and were more likely to report depression and back pain. Compared to the other two classes, patients in the All High class had fewer years of education and a higher number of comorbidities. Significant differences were found among the three classes for comorbidity burden and total number of MSAS symptoms (i.e., All Low < Moderate < All High), as well as for performance status (i.e., All Low > Moderate > All High). A higher symptom burden was associated with poorer QOL outcomes. CONCLUSIONS: The first study to identify subgroups of patients with GI cancers based on distinct symptom profiles. LCA allowed for the identification of risk factors associated with a higher symptom burden. Clinicians can use this information to identify high-risk patients and develop personalized symptom management interventions.

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Published In

Support Care Cancer

DOI

EISSN

1433-7339

Publication Date

August 2021

Volume

29

Issue

8

Start / End Page

4461 / 4471

Location

Germany

Related Subject Headings

  • Risk Factors
  • Quality of Life
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Gastrointestinal Neoplasms
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Lin, Y., Bailey, D. E., Docherty, S. L., Porter, L. S., Cooper, B. A., Paul, S. M., … Miaskowski, C. (2021). Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy. Support Care Cancer, 29(8), 4461–4471. https://doi.org/10.1007/s00520-020-05946-4
Lin, Yufen, Donald E. Bailey, Sharron L. Docherty, Laura S. Porter, Bruce A. Cooper, Steven M. Paul, Kord M. Kober, et al. “Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.Support Care Cancer 29, no. 8 (August 2021): 4461–71. https://doi.org/10.1007/s00520-020-05946-4.
Lin Y, Bailey DE, Docherty SL, Porter LS, Cooper BA, Paul SM, et al. Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy. Support Care Cancer. 2021 Aug;29(8):4461–71.
Lin, Yufen, et al. “Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.Support Care Cancer, vol. 29, no. 8, Aug. 2021, pp. 4461–71. Pubmed, doi:10.1007/s00520-020-05946-4.
Lin Y, Bailey DE, Docherty SL, Porter LS, Cooper BA, Paul SM, Kober KM, Hammer MJ, Wright F, Dunn LB, Conley YP, Levine JD, Miaskowski C. Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy. Support Care Cancer. 2021 Aug;29(8):4461–4471.
Journal cover image

Published In

Support Care Cancer

DOI

EISSN

1433-7339

Publication Date

August 2021

Volume

29

Issue

8

Start / End Page

4461 / 4471

Location

Germany

Related Subject Headings

  • Risk Factors
  • Quality of Life
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Gastrointestinal Neoplasms
  • Female