Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease.
Publication
, Journal Article
Fudim, M; Sobotka, PA; Dunlap, ME
Published in: Circ Heart Fail
January 2021
While many of the cardiac limitations to exercise performance are now well-characterized, extracardiac limitations to exercise performance have been less well recognized but are nevertheless important. We propose that abnormalities of cardiac preload reserve represents an under-recognized but common cause of exercise limitations. We further propose that mechanistic links exist between conditions as seemingly disparate as heart failure with preserved ejection fraction, nonalcoholic fatty liver disease, and pelvic venous compression/obstruction syndromes (eg, May-Thurner). We conclude that extracardiac abnormalities of preload reserve serve as a major pathophysiologic mechanism underlying these and other disease states.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Circ Heart Fail
DOI
EISSN
1941-3297
Publication Date
January 2021
Volume
14
Issue
1
Start / End Page
e007308
Location
United States
Related Subject Headings
- Veins
- Vascular Capacitance
- Syncope, Vasovagal
- Stroke Volume
- Postural Orthostatic Tachycardia Syndrome
- Non-alcoholic Fatty Liver Disease
- May-Thurner Syndrome
- Liver Diseases
- Humans
- Hemodynamics
Citation
APA
Chicago
ICMJE
MLA
NLM
Fudim, M., Sobotka, P. A., & Dunlap, M. E. (2021). Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease. Circ Heart Fail, 14(1), e007308. https://doi.org/10.1161/CIRCHEARTFAILURE.120.007308
Fudim, Marat, Paul A. Sobotka, and Mark E. Dunlap. “Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease.” Circ Heart Fail 14, no. 1 (January 2021): e007308. https://doi.org/10.1161/CIRCHEARTFAILURE.120.007308.
Fudim M, Sobotka PA, Dunlap ME. Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease. Circ Heart Fail. 2021 Jan;14(1):e007308.
Fudim, Marat, et al. “Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease.” Circ Heart Fail, vol. 14, no. 1, Jan. 2021, p. e007308. Pubmed, doi:10.1161/CIRCHEARTFAILURE.120.007308.
Fudim M, Sobotka PA, Dunlap ME. Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease. Circ Heart Fail. 2021 Jan;14(1):e007308.
Published In
Circ Heart Fail
DOI
EISSN
1941-3297
Publication Date
January 2021
Volume
14
Issue
1
Start / End Page
e007308
Location
United States
Related Subject Headings
- Veins
- Vascular Capacitance
- Syncope, Vasovagal
- Stroke Volume
- Postural Orthostatic Tachycardia Syndrome
- Non-alcoholic Fatty Liver Disease
- May-Thurner Syndrome
- Liver Diseases
- Humans
- Hemodynamics