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Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid.

Publication ,  Journal Article
Ruzicka, K; Strader, LC; Bailly, A; Yang, H; Blakeslee, J; Langowski, L; Nejedlá, E; Fujita, H; Itoh, H; Syono, K; Hejátko, J; Gray, WM ...
Published in: Proceedings of the National Academy of Sciences of the United States of America
June 2010

Differential distribution of the plant hormone auxin within tissues mediates a variety of developmental processes. Cellular auxin levels are determined by metabolic processes including synthesis, degradation, and (de)conjugation, as well as by auxin transport across the plasma membrane. Whereas transport of free auxins such as naturally occurring indole-3-acetic acid (IAA) is well characterized, little is known about the transport of auxin precursors and metabolites. Here, we identify a mutation in the ABCG37 gene of Arabidopsis that causes the polar auxin transport inhibitor sensitive1 (pis1) phenotype manifested by hypersensitivity to auxinic compounds. ABCG37 encodes the pleiotropic drug resistance transporter that transports a range of synthetic auxinic compounds as well as the endogenous auxin precursor indole-3-butyric acid (IBA), but not free IAA. ABCG37 and its homolog ABCG36 act redundantly at outermost root plasma membranes and, unlike established IAA transporters from the PIN and ABCB families, transport IBA out of the cells. Our findings explore possible novel modes of regulating auxin homeostasis and plant development by means of directional transport of the auxin precursor IBA and presumably also other auxin metabolites.

Duke Scholars

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

June 2010

Volume

107

Issue

23

Start / End Page

10749 / 10753

Related Subject Headings

  • Plant Roots
  • Mutation
  • Indoles
  • Indoleacetic Acids
  • Homeostasis
  • Base Sequence
  • Arabidopsis Proteins
  • Arabidopsis
  • ATP-Binding Cassette Transporters
  • ATP Binding Cassette Transporter, Subfamily G
 

Citation

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Ruzicka, K., Strader, L. C., Bailly, A., Yang, H., Blakeslee, J., Langowski, L., … Friml, J. (2010). Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. Proceedings of the National Academy of Sciences of the United States of America, 107(23), 10749–10753. https://doi.org/10.1073/pnas.1005878107
Ruzicka, Kamil, Lucia C. Strader, Aurélien Bailly, Haibing Yang, Joshua Blakeslee, Lukasz Langowski, Eliska Nejedlá, et al. “Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid.Proceedings of the National Academy of Sciences of the United States of America 107, no. 23 (June 2010): 10749–53. https://doi.org/10.1073/pnas.1005878107.
Ruzicka K, Strader LC, Bailly A, Yang H, Blakeslee J, Langowski L, et al. Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. Proceedings of the National Academy of Sciences of the United States of America. 2010 Jun;107(23):10749–53.
Ruzicka, Kamil, et al. “Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid.Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 23, June 2010, pp. 10749–53. Epmc, doi:10.1073/pnas.1005878107.
Ruzicka K, Strader LC, Bailly A, Yang H, Blakeslee J, Langowski L, Nejedlá E, Fujita H, Itoh H, Syono K, Hejátko J, Gray WM, Martinoia E, Geisler M, Bartel B, Murphy AS, Friml J. Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. Proceedings of the National Academy of Sciences of the United States of America. 2010 Jun;107(23):10749–10753.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

June 2010

Volume

107

Issue

23

Start / End Page

10749 / 10753

Related Subject Headings

  • Plant Roots
  • Mutation
  • Indoles
  • Indoleacetic Acids
  • Homeostasis
  • Base Sequence
  • Arabidopsis Proteins
  • Arabidopsis
  • ATP-Binding Cassette Transporters
  • ATP Binding Cassette Transporter, Subfamily G