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Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure.

Publication ,  Journal Article
Feng, KY; O'Connor, CM; Clare, R; Alhanti, B; Piña, IL; Kraus, WE; Whellan, DJ; Mentz, RJ
Published in: J Cardiovasc Transl Res
October 2021

We examined the relationship between pain severity and outcomes in patients with heart failure with reduced ejection fraction (HFrEF) in the HF-ACTION randomized controlled trial. Trends of health-related quality of life (HRQoL) measures grouped by patients' self-reported baseline bodily pain severity were compared using correlation tests, and the association between pain severity and clinical outcomes (including a primary composite endpoint of all-cause mortality and all-cause hospitalization) was assessed using multivariable adjusted analyses. Of the 2310 patients, 22.9% reported no pain, 45.8% very mild/mild, 24.9% moderate, and 6.4% severe/very severe. Greater pain severity was associated with worse HRQoL measures (EuroQoL-5D-3L and Kansas City Cardiomyopathy Questionnaire; both p < 0.0001). Compared to those reporting no pain, patients reporting severe/very severe pain had greater risk for the primary endpoint (adjusted hazard ratio 1.42, 95% confidence interval 1.11-1.83, p = 0.01). In patients with HFrEF, greater pain severity was associated with worse HRQoL and clinical outcomes. Trial Registration: NCT00047437.

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Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

October 2021

Volume

14

Issue

5

Start / End Page

984 / 991

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Severity of Illness Index
  • Risk Factors
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Prognosis
  • Predictive Value of Tests
  • Pain Measurement
 

Citation

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Feng, K. Y., O’Connor, C. M., Clare, R., Alhanti, B., Piña, I. L., Kraus, W. E., … Mentz, R. J. (2021). Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure. J Cardiovasc Transl Res, 14(5), 984–991. https://doi.org/10.1007/s12265-021-10104-0
Feng, Kent Y., Christopher M. O’Connor, Robert Clare, Brooke Alhanti, Ileana L. Piña, William E. Kraus, David J. Whellan, and Robert J. Mentz. “Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure.J Cardiovasc Transl Res 14, no. 5 (October 2021): 984–91. https://doi.org/10.1007/s12265-021-10104-0.
Feng KY, O’Connor CM, Clare R, Alhanti B, Piña IL, Kraus WE, et al. Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure. J Cardiovasc Transl Res. 2021 Oct;14(5):984–91.
Feng, Kent Y., et al. “Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure.J Cardiovasc Transl Res, vol. 14, no. 5, Oct. 2021, pp. 984–91. Pubmed, doi:10.1007/s12265-021-10104-0.
Feng KY, O’Connor CM, Clare R, Alhanti B, Piña IL, Kraus WE, Whellan DJ, Mentz RJ. Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure. J Cardiovasc Transl Res. 2021 Oct;14(5):984–991.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

October 2021

Volume

14

Issue

5

Start / End Page

984 / 991

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Severity of Illness Index
  • Risk Factors
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Prognosis
  • Predictive Value of Tests
  • Pain Measurement