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Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity.

Publication ,  Journal Article
Hong, GJ; Koerner, JC; Weinert, MC; Stinnett, SS; Freedman, SF; Wallace, DK; Riggins, JW; Gallaher, KJ; Prakalapakorn, SG
Published in: J AAPOS
February 2021

PURPOSE: To quantitatively compare retinal vascular characteristics over time in eyes eventually treated versus not treated for retinopathy of prematurity (ROP), using ROPtool analysis of narrow-field retinal images. METHODS: This longitudinal study used prospectively collected narrow-field retinal images of infants screened for ROP, prior to treatment, if needed. Images were analyzed using a methodology that combines quadrant-level measures from several images of the same eye. For the longitudinal analysis, one examination per postmenstrual age (PMA) was included per eye. We compared the following ROPtool indices and their change per week between eyes eventually treated versus not treated for ROP: tortuosity index (TI), dilation index (DI), sum of adjusted indices (SAI), and tortuosity-weighted plus (TWP). Analysis was performed on three levels: eye (mean value/eye), quadrant (highest quadrant value/eye), and blood vessel (highest blood vessel value/eye). RESULTS: Of 832 examinations (99 infants), 745 images (89.5%) had 3-4 quadrants analyzable by ROPtool. On the eye level, ROPtool indices differed between eyes eventually treated versus not treated at PMA of 33-35 and 37 weeks for TI, SAI, and TWP, and at PMA of 33-34 and 37 weeks for DI (P ≤ 0.0014), and change per week differed between eyes eventually treated versus not treated only for SAI at PMA of 32 weeks (P < 0.001). CONCLUSIONS: Quantitative analysis of retinal vascular characteristics using ROPtool can help predict eventual need for treatment for ROP as early as 32 weeks PMA. ROPtool index values were more useful than change in these indices to predict eyes that would eventually need treatment for ROP.

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Published In

J AAPOS

DOI

EISSN

1528-3933

Publication Date

February 2021

Volume

25

Issue

1

Start / End Page

25.e1 / 25.e7

Location

United States

Related Subject Headings

  • Retinopathy of Prematurity
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Longitudinal Studies
  • Infant, Newborn
  • Infant
  • Humans
  • Gestational Age
  • Eye
  • Diagnosis, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hong, G. J., Koerner, J. C., Weinert, M. C., Stinnett, S. S., Freedman, S. F., Wallace, D. K., … Prakalapakorn, S. G. (2021). Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity. J AAPOS, 25(1), 25.e1-25.e7. https://doi.org/10.1016/j.jaapos.2020.08.015
Hong, Gloria J., Jagger C. Koerner, Marguerite C. Weinert, Sandra S. Stinnett, Sharon F. Freedman, David K. Wallace, J Wayne Riggins, Keith J. Gallaher, and S Grace Prakalapakorn. “Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity.J AAPOS 25, no. 1 (February 2021): 25.e1-25.e7. https://doi.org/10.1016/j.jaapos.2020.08.015.
Hong GJ, Koerner JC, Weinert MC, Stinnett SS, Freedman SF, Wallace DK, et al. Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity. J AAPOS. 2021 Feb;25(1):25.e1-25.e7.
Hong, Gloria J., et al. “Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity.J AAPOS, vol. 25, no. 1, Feb. 2021, pp. 25.e1-25.e7. Pubmed, doi:10.1016/j.jaapos.2020.08.015.
Hong GJ, Koerner JC, Weinert MC, Stinnett SS, Freedman SF, Wallace DK, Riggins JW, Gallaher KJ, Prakalapakorn SG. Quantitatively comparing weekly changes in retinal vascular characteristics of eyes eventually treated versus not treated for retinopathy of prematurity. J AAPOS. 2021 Feb;25(1):25.e1-25.e7.
Journal cover image

Published In

J AAPOS

DOI

EISSN

1528-3933

Publication Date

February 2021

Volume

25

Issue

1

Start / End Page

25.e1 / 25.e7

Location

United States

Related Subject Headings

  • Retinopathy of Prematurity
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Longitudinal Studies
  • Infant, Newborn
  • Infant
  • Humans
  • Gestational Age
  • Eye
  • Diagnosis, Computer-Assisted